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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 9
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Animal Pharmacokinetics and Metabolism

Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution

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Pages 794-802 | Received 09 Dec 2014, Accepted 25 Jan 2015, Published online: 27 Apr 2015

References

  • Borders-Hemphill V. (2009). Concurrent use of statins and amiodarone. Consult Pharm 24:372–9
  • Bottorff MB. (2006). Statin safety and drug interactions: clinical implications. Am J Cardiol 97:27C–31C
  • Chen GM, Hu N, Liu L, et al. (2011). Pharmacokinetics of verapamil in diabetic rats induced by combination of high-fat diet and streptozotocin injection. Xenobiotica 41:494–500
  • Colhoun HM, Betteridge DJ, Durrington PN, et al. (2004). Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 364:685–96
  • Ellis LC, Hawksworth GM, Weaver RJ. (2013). ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol 269:187–94
  • Hasegawa Y, Kishimoto S, Shibatani N, et al. (2010). The disposition of pravastatin in a rat model of streptozotocin-induced diabetes and organic anion transporting polypeptide 2 and multidrug resistance-associated protein 2 expression in the liver. Biol Pharm Bull 33:153–6
  • Ishigami M, Tokui T, Komai T, et al. (1995). Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes. Pharm Res 12:1741–5
  • Kalliokoski A, Niemi M. (2009). Impact of OATP transporters on pharmacokinetics. Br J Pharmacol 158:693–705
  • Kobayashi D, Nozawa T, Imai K, et al. (2003). Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther 306:703–8
  • Komai T, Kawai K, Tokui T, et al. (1992a). Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys. Eur J Drug Metab Pharmacokinet 17:103–13
  • Komai T, Shigehara E, Tokui T, et al. (1992b). Carrier-mediated uptake of pravastatin by rat hepatocytes in primary culture. Biochem Pharmacol 43:667–70
  • Li F, Zhang M, Xu D, et al. (2014). Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure. Acta Pharmacol Sin 35:792–805
  • Liu C, Zhang M, Hu MY, et al. (2013). Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides. J Endocrinol 217:185–96
  • Liu H, Liu L, Li J, et al. (2012). Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus. Drug Metab Dispos 40:1104–12
  • MacLean C, Moenning U, Reichel A, Fricker G. (2010). Regional absorption of fexofenadine in rat intestine. Eur J Pharm Sci 41:670–4
  • Mei D, Li J, Liu H, et al. (2012). Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats. Xenobiotica 42:709–18
  • Moreno G, Mangione CM. (2013). Management of cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: 2002–2012 literature review. J Am Geriatr Soc 61:2027–37
  • Niemi M, Backman JT, Kajosaari LI, et al. (2005). Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics. Clin Pharmacol Ther 77:468–78
  • Ogura J, Koizumi T, Segawa M, et al. (2014). Quercetin-3-rhamnoglucoside (rutin) stimulates transport of organic anion compounds mediated by organic anion transporting polypeptide 2B1. Biopharm Drug Dispos 35:173–82
  • Roten L, Schoenenberger RA, Krahenbuhl S, Schlienger RG. (2004). Rhabdomyolysis in association with simvastatin and amiodarone. Ann Pharmacother 38:978–81
  • Schachter M. (2005). Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol 19:117–25
  • Tamai I, Takanaga H, Maeda H, et al. (1995). Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm Res 12:1727–32
  • Tokui T, Nakai D, Nakagomi R, et al. (1999). Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2. Pharm Res 16:904–8
  • Varma MV, Lin J, Bi YA, et al. (2013). Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin. Drug Metab Dispos 41:966–74
  • Varma MV, Rotter CJ, Chupka J, et al. (2011). pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1. Mol Pharm 8:1303–13
  • Watanabe T, Kusuhara H, Maeda K, et al. (2009). Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans. J Pharmacol Exp Ther 328:652–62

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