Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 11
222
Views
11
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration

, &
Pages 999-1008 | Received 04 Feb 2015, Accepted 09 Mar 2015, Published online: 18 Jun 2015

References

  • Alonso-Castro AJ, Zapata-Bustos R, Gómez-Espinoza G, Salazar-Olivo LA. (2012). Isoorientin reverts TNF-α-induced insulin resistance in adipocytes activating the insulin signaling pathway. Endocrinology 153:5222–30
  • Blanchard RL, Freimuth RR, Buck J, et al. (2004). A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics 14:199–211
  • Cao J, Xia X, Dai X, et al. (2013). Flavonoids profiles, antioxidant, acetylcholinesterase inhibition activities of extract from Dryoathyrium boryanum (Willd.) Ching. Food Chem Toxicol 55:121–8
  • Chen ZJ, Chen M, Pan H, et al. (2011). Role of catechol-O-methyltransferase in the disposition of luteolin in rats. Drug Metab Dispos 39:667–74
  • Cui ZH, Li Y, Wang ZW, et al. (2013). Chemical constituents from Gentianopsis barbata var. sinensis Ma (Gentianaceae). Biochem Sys Ecol 47:101–3
  • Donovan JL, Bell JR, Kasim-Karakas S, et al. (1999). Catechin is present as metabolites in human plasma after consumption of red wine. J Nutr 129:1662–8
  • Francisco V, Figueirinha A, Costa G, et al. (2014). Chemical characterization and antiinflammatory activity of luteolin glycosides isolated from lemongrass. J Func Foods 10:436–43
  • Galijatovic A, Otake Y, Walle UK, Walle T. (2001). Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells–potential role in carcinogen bioinactivation. Pharm Res 18:374–9
  • Gonthier M-P, Donovan JL, Texier O, et al. (2003). Metabolism of dietary procyanidins in rats. Free Radic Biol Med 35:837–44
  • Grace OM, Simmonds MSJ, Smith GF, van Wyk AE. (2010). Chemosystematic evaluation of Aloe section Pictae (Asphodelaceae). Biochem Sys Ecol 38:57–62
  • Gradolatto A, Canivenc-Lavier MC, Basly JP, et al. (2004). Metabolism of apigenin by rat liver phase I and phase II enzymes and by isolated perfused rat liver. Drug Metab Dispos 32:58–65
  • Havsteen BH. (2002). The biochemistry and medicinal significance of the flavonoids. Pharmacol Ther 96:67–202
  • Hu M, Chen JN, Lin HM. (2003). Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the caco-2 cell culture model. J Pharmacol Exp Ther 307:314–21
  • Li H, Song F, Xing J, et al. (2009). Screening and structural characterization of α-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MSn and SORI-CID FTICR MS. J Am Soc Mass Spectrom 20:1496–503
  • López-Vargas JH, Fernández-López J, Pérez-Álvarez JA, Viuda-Martos M. (2013). Chemical, physico-chemical, technological, antibacterial and antioxidant properties of dietary fiber powder obtained from yellow passion fruit (Passiflora edulis var. flavicarpa) co-products. Food Res Int 51:756–63
  • Luo CF, Cai B, Hou N, et al. (2012). UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human. Arch Toxicol 86:1681–90
  • Marzouk MM, Hussein SR, Ibrahim LF, et al. (2014). Flavonoids from Neurada procumbens L. (Neuradaceae) in Egypt. Biochem Sys Ecol 57:67–8
  • Pacifico S, Scognamiglio M, D’Abrosc B, et al. (2010). Spectroscopic characterization and antiproliferative activity on HepG2 human hepatoblastoma cells of flavonoid C-glycosides from Petrorhagia velutina. J Nat Prod 73:1973–8
  • Sheng N, Zhi X, Yuan L, et al. (2014). Pharmacokinetic and excretion study of three secoiridoid glycosides and three flavonoid glycosides in rat by LC–MS/MS after oraladministration of the Swertia pseudochinensis extract. J Chromatogr B 967:75–83
  • Takahashi S, Sakakibara Y, Mishiro E, et al. (2009). Molecular cloning, expression and characterization of a novel mouse SULT6 cytosolic sulfotransferase. J Biochem 146:399–405
  • Vaidyanathan JB, Walle T. (2002). Glucuronidation and sulfation of the tea flavonoid (−)-epicatechin by the human and rat enzymes. Drug Metab Dispos 30:897–903
  • Walle T, Walle UK, Halushka PV. (2001). Carbon dioxide is the major metabolite of quercetin in humans. J Nutr 131:2648–52
  • Yao H, Chen Y, Shi P, et al. (2012). Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R. Br using HPLC-DAD–ESI/MS coupled with pre-column DPPH assay. Food Chem 135:2802–7
  • Yuan L, Ren X, Wu Y, et al. (2013a). Isoorientin protects BRL-3A rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating MAPKs, activating Akt and scavenging ROS and NO. Biomed Aging Pathol 3:153–9
  • Yuan L, Wang J, Xiao H, et al. (2012). Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. Toxicol Appl Pharmacol 265:83–92
  • Yuan L, Wang J, Xiao H, et al. (2013b). MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells. Food Chem Toxicol 53:62–8
  • Yuan L, Wu Y, Ren X, et al. (2014). Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia. Mol Cell Biochem 386:153–65
  • Zhang Y, Tie XW, Bao BL, et al. (2007). Metabolism of flavone C-glucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats. Br J Nutr 97:484–94

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.