Metabolic fate analysis of Huang–Lian–Jie–Du Decoction in rat urine and feces by LC–IT-MS combining with LC–FT-ICR-MS: a feasible strategy for the metabolism study of Chinese medical formula

References

• Chen HX, Huang JL, Li J. (2010). Structural elucidation of in vivo and in vitro metabolites of epiberberine in rat and its liver and intestines by liquid chromatography–tandem mass spectrometry. Anal Lett 43:2505–17
   Web of Science ®Google Scholar
• Deng YT, Liao QF, Li SH, et al. (2008). Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography–tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis–evodia herb couple. J Chromatogr B 863:195–205
   PubMed Web of Science ®Google Scholar
• Ding Y, Hou JW, Zhang Y, et al. (2013). Metabolism of genipin in rat and identification of metabolites by using ultraperformance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry. Evid Based Complement Alternat Med 2013:1–13
   Google Scholar
• Dou SS, Liu L, Jiang P, et al. (2009). LC–DAD and LC–ESI–MS chromatographic fingerprinting and quantitative analysis for evaluation of the quality of Huang-Lian-Jie-Du-Tang. Chromatographia 69:659–64
   Web of Science ®Google Scholar
• Dunn WB, Erban A, Weber RJ, et al. (2013). Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. Metabolomics 9:44–66
   Web of Science ®Google Scholar
• Horvath CR, Martos PA, Saxena PK. (2005). Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant Huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. J Chromatogr A 1062:199–207
   PubMed Web of Science ®Google Scholar
• Hu YH, Jiang P, Wang SP, et al. (2012). Plasma pharmacochemistry based approach to screening potential bioactive components in Huang-Lian-Jie-Du-Tang using high performance liquid chromatography coupled with mass spectrometric detection. J Ethnopharmacol 141:728–35
   PubMed Web of Science ®Google Scholar
• Hu YM, Su GH, Sze SCW, et al. (2010). Quality assessment of Cortex Phellodendri by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry. Biomed Chromatogr 24:438–53
   PubMed Web of Science ®Google Scholar
• Jiang X, Huang LF, Wu LB, et al. (2012). UPLC-QTOF/MS analysis of alkaloids in traditional processed Coptis chinensis Franch. Evid Based Complement Alternat Med 2012:1–6
   Web of Science ®Google Scholar
• Kassahun K, Black WC, Nicoll-Griffith D, et al. (2011). Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin K inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway. Drug Metab Dispos 39:1079–87
   PubMed Web of Science ®Google Scholar
• Lai MY, Hsiu SL, Chen CC, et al. (2003). Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Biol Pharm Bull 26:79–83
   PubMed Web of Science ®Google Scholar
• Li XX, Li CB, Ji XP, et al. (2008). Huang-Lian-Jie-Du-Tang inhibits myocardial remodeling in a rat model of metabolic syndrome. J Ethnopharmacol 119:259–65
   PubMed Web of Science ®Google Scholar
• Li J, Wang YH, Smillie TJ, Khan IA. (2012). Identification of phenolic compounds from Scutellaria lateriflora by liquid chromatography with ultraviolet photodiode array and electrospray ionization tandem mass spectrometry. J Pharmaceut Biomed 63:120–7
   PubMed Web of Science ®Google Scholar
• Liu QX, Liang T, Li KY, et al. (2012). Preparation of a stationary phase with quaternary ammonium embedded group for selective separation of alkaloids based on ion-exclusion interaction. J Sep Sci 35:2685–92
   PubMed Web of Science ®Google Scholar
• Liu GZ, Ma JY, Chen YZ, et al. (2009). Investigation of flavonoid profile of Scutellaria baicalensis Georgi by high performance liquid chromatography with diode array detection and electrospray ion trap mass spectrometry. J Chromatogr A 1216:4809–14
   PubMed Web of Science ®Google Scholar
• Liu QX, Qiu SY, Yu H, et al. (2011b). Selective separation of structure-related alkaloids in Rhizoma Coptidis with “click” binaphthyl stationary phase and their structural elucidation with liquid chromatography–mass spectrometry. Analyst 136:4357–65
   PubMed Web of Science ®Google Scholar
• Liu GZ, Rajesh N, Wang XS, et al. (2011a). Identification of flavonoids in the stems and leaves of Scutellaria baicalensis Georgi. J Chromatogr B 879:1023–8
   PubMed Web of Science ®Google Scholar
• Lu J, Wang JS, Kong LY. (2011). Anti-inflammatory effects of Huang-Lian-Jie-Du Decoction, its two fractions and four typical compounds. J Ethnopharmacol 134:911–18
   PubMed Web of Science ®Google Scholar
• Malikov V, Yuldashev M. (2002). Phenolic compounds of plants of the Scutellaria L. genus. Distribution, structure and properties. Chem Nat Compd 38:358–406
   Web of Science ®Google Scholar
• Montoro P, Maldini M, Piacente S, et al. (2010). Metabolite fingerprinting of camptotheca acuminata and the HPLC-ESI-MS/MS analysis of camptothecin and related alkaloids. J Pharmaceut Biomed 51:405–15
   PubMed Web of Science ®Google Scholar
• Nikolić D, Gödecke T, Chen SN, et al. (2012). Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia 83:441–60
   PubMed Web of Science ®Google Scholar
• Qin KM, Guo H, Xu ZS, et al. (2011). Research status of chemical constituents and pharmacokinetics of Huanglian Jiedu Tang. Anti Infect Pharm 8:3–7
   Google Scholar
• Qiu F, Zhu ZY, Kang N, et al. (2008). Isolation and identification of urinary metabolites of berberine in rats and humans. Drug Metab Dispos 36:2159–65
   PubMed Web of Science ®Google Scholar
• Ren Y, Wang PY, Wu CS, et al. (2013). Identification of the metabolites after oral administration of extract of ziziphi spinosae semen to rats or dogs by high-performance liquid chromatography/linear ion trap FTICR hybrid mass spectrometry. Biomed Chromatogr 27:17–26
   PubMed Web of Science ®Google Scholar
• Shang XF, He XR, He XY, et al. (2010). The genus Scutellaria an ethnopharmacological and phytochemical review. J Ethnopharmacol 128:279–313
   PubMed Web of Science ®Google Scholar
• Sun J, Wen QH, Li X, et al. (2006). Comparison between antitumor effect and chemical constituents of Huanglian Jiedu decoction and that of serum containing Huanglian Jiedu decoction. Chin J Chin Mater Med 31:1526–9
   Google Scholar
• Tang XL, Tang M. (2010). Advances in studies on clinical effect in Huanglian JieduTang. Pract Clin J Integr Tradit Chin West Med 10:90–2
   Google Scholar
• Trinh HT, Joh EH, Kwak HY, et al. (2010). Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice. Acta Pharmacol Sin 31:718–24
   PubMed Web of Science ®Google Scholar
• Wang Y, He YZ, Zhang QY. (1994). The research progress of Huanglian Jiedu decoction in Japan. Inform. Tradit Chin Med 1:38–40
   Google Scholar
• Want EJ, Wilson ID, Gika H, et al. (2010). Global metabolic profiling procedures for urine using UPLC–MS. Nat Protoc 5:1005–18
   PubMed Web of Science ®Google Scholar
• Xiang C, Qiao X, Wang Q, et al. (2011). From single compounds to herbal extract: a strategy to systematically characterize the metabolites of licorice in rats. Drug Metab Dispos 39:1597–608
   PubMed Web of Science ®Google Scholar
• Xu JH, Murakami Y, Matsumoto K, et al. (2000). Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. J Ethnopharmacol 73:405–13
   PubMed Web of Science ®Google Scholar
• Yang W, Chen Y, Xi C, et al. (2013a). Liquid chromatography–tandem mass spectrometry-based plasma metabonomics delineate the effect of metabolites’ stability on reliability of potential biomarkers. Anal Chem 85:2606–10
   PubMed Web of Science ®Google Scholar
• Yang Y, Wang HJ, Yang J, et al. (2013b). Chemical profiling and quantification of Chinese medicinal formula Huang–Lian–Jie–Du Decoction, a systematic quality control strategy using ultra high performance liquid chromatography combined with hybrid quadrupole-orbitrap and triple quadrupole mass spectrometers. J Chromatogr A 1321:88–99
   PubMed Web of Science ®Google Scholar
• Yang Y, Zhao HY, Song JF, et al. (2013c). The chemical isolation study and related neuroprotective effect of Huang-Lian-Jie-Du Decoction. Lishizhen Med Mater Medica Res 24:1599–630
   Google Scholar
• Zeng HW, Liu XH, Dou SS, et al. (2009). Huang–Lian–Jie–Du–Tang exerts anti-inflammatory effects in rats through inhibition of nitric oxide production and eicosanoid biosynthesis via the lipoxygenase pathway. J Pharm Pharmacol 61:1699–707
   PubMed Web of Science ®Google Scholar
• Zhang QC, Qian ZL, Pan LM, et al. (2011a). The traditional Chinese medicine Huang–Lian–Jie–Du–Tang inhibits hypoxia-induced neuronal apoptosis. Afr J Pharm Pharmacol 5:2558–65
   Google Scholar
• Zhang W, Saif MW, Dutschman GE, et al. (2010). Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS). J Chromatogr A 1217:5785–93
   PubMed Web of Science ®Google Scholar
• Zhang ZW, Yue GH, Zhang AZ. (2011b). Effects of Huang–Lian–Jie–Du–Tang-Decoction on blood pressure and inflammatory factors in spontaneous hypertension rats. Zhonghua Zhongyiyao Zazhi 26:1627–9
   Google Scholar
• Zhou TT, Liu H, Wen J, et al. (2010). Fragmentation study of iridoid glycosides including epimers by liquid chromatography-diode array detection/electrospray ionization mass spectrometry and its application in metabolic fingerprint analysis of Gardenia jasminoides Ellis. Rapid Commun Mass Spectrom 24:2520–8
   PubMed Web of Science ®Google Scholar
• Zhu SL, Dou SS, Liu XR, et al. (2011). Qualitative and quantitative analysis of alkaloids in Cortex Phellodendri by HPLC–ESI-MS/MS and HPLC-DAD. Chem Res Chin Univ 27:38–44
   Web of Science ®Google Scholar
• Zhu MM, Han FM, Chen HX, et al. (2007). Identification of palmatine and its metabolites in rat urine by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 21:2019–22
   PubMed Web of Science ®Google Scholar
• Zhu HX, Qian ZL, Li H, et al. (2012). Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang–Lian–Jie–Du–Tang. J Ethnopharmacol 141:158–69
   PubMed Web of Science ®Google Scholar
• Zuo F, Nakamura N, Akao T, Hattori M. (2006). Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos 34:2064–72
   PubMed Web of Science ®Google Scholar
• Zuo R, Wang HJ, Si N, et al. (2014). LC–FT-ICR-MS analysis of the prototypes and metabolites in rat plasma after administration of Huang–Lian–Jie–Du Decoction. Acta Pharm Sin 49:237–43
   Google Scholar