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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 2
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Animal pharmacokinetics and metabolism

Route of administration and formulation dependent pharmacokinetics of 17-hydroxyprogesterone caproate in rats

Imam H. ShaikDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA,
,
Jaime R. BastianDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA, ;Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, Magee-Women’s Hospital, Pittsburgh, PA, USA,
,
Yang ZhaoDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA,
,
Steve N. CaritisDepartment of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, Magee-Women’s Hospital, Pittsburgh, PA, USA, ;Magee-Women’s Research Institute, Pittsburgh, PA, USA, and
&
Raman VenkataramananDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA, ;Magee-Women’s Research Institute, Pittsburgh, PA, USA, and ;Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USACorrespondence[email protected]
Pages 169-174 | Received 08 Apr 2015, Accepted 29 May 2015, Published online: 07 Jul 2015

References

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  • Caritis SN, Venkataramanan R, Thom E, et al.; Eunice Kennedy Shriver National Institute of Child, H., Human Development Maternal–Fetal Medicine Units, N. & Obstetric-Fetal Pharmacology Research Units, N. (2014). Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth. Am J Obstet Gynecol 210:128e1–6
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  • Sharma S, Ellis EC, Dorko K, et al. (2010). Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes. Drug Metab Dispos 38:723–7
  • Sharma S, Ou J, Strom S, et al. (2008). Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth. Drug Metab Dispos 36:1896–902
  • Yan R, Nanovskaya TN, Zharikova OL, et al. (2008). Metabolism of 17alpha-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons. Biochem Pharmacol 75:1848–57
  • Zhang S, Mada SR, Sharma S, et al. (2008). Simultaneous quantitation of 17alpha-hydroxyprogesterone caproate, 17alpha-hydroxyprogesterone and progesterone in human plasma using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS). J Pharm Biomed Anal 48:1174–80

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