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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 5
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General Xenobiochemistry

Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study

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Pages 385-392 | Received 03 Jul 2015, Accepted 05 Aug 2015, Published online: 31 Aug 2015

References

  • Adembri C, Selmi V, Vitali L, et al. (2014). Minocycline but not tigecycline Is neuroprotective and reduces the neuroinflammatory response Induced by the superimposition of sepsis upon traumatic brain injury. Crit Care Med 42:570–82
  • Agwuh KN, Macgowan A. (2006). Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother 58:256–65
  • Baijnath S, Naiker S, Shobo A, et al. (2015). Evidence for the presence of clofazimine and its distribution in the healthy mouse brain. J Mol Histol 46:439–42
  • Bratkowska D, Shobo A, Singh S, et al. (2015). Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study. J Chromatogr B 988:187–94
  • Clark WM, Calcagno FA, Gabler WL, et al. (1994). Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment. Stroke 25:1411–15
  • Colovic M, Caccia S. (2003). Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat. J Chromatogr B 791:337–43
  • Cunha B, Domenico P, Cunha C. (2000). Pharmacodynamics of doxycycline. Clin Microbiol Infect 6:270–73
  • Fagan SC, Edwards DJ, Borlongan CV, et al. (2004). Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection. Exp Neurol 186:248–51
  • Goodwin RJ, Mackay CL, Nilsson A, et al. (2011). Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method. Anal Chem 83:9694–701
  • Heeren RM. (2014). Getting the picture: the coming of age of imaging MS. Int J Mass Spectrom 377:672–80
  • Jantzie LL, Cheung PY, Tood KG. (2005). Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia-ischemia. J Cereb Blood Flow Metab 25:314–24
  • Jantzie LL, Rauw GA, Tood KG. (2006). The effects of doxycycline administration on amino acid neurotransmitters in an animal model of neonatal hypoxia-ischemia. Neurochem Int 49:717–28
  • Jantzie LL, Tood KG. (2010). Doxycycline inhibits proinflammatory cytokines but not acute cerebral cytogenesis after hypoxia–ischemia in neonatal rats. J Psychiatry Neurosci 35:20
  • Jayewardene AL, Kearney B, Stone JA, et al. (2001). An LC-MS-MS method for the determination of indinavir, an HIV-1 protease inhibitor, in human plasma. J Pharm Biomed Anal 25:309–17
  • Junior LB, De Toni Uchoa F, Guterries SS, et al. (2009). Development and validation of LC-MS/MS method for the simultaneous determination of quinine and doxycycline in pharmaceutical formulations. J Liq Chromatogr R T 32:2699–711
  • Junior LB, Leal MG, De Toni Uchoa F, et al. (2011). Determination of quinine and doxycycline in rat plasma by LC–MS–MS: application to a pharmacokinetic study. Chromatographia 73:1081–8
  • Kogawa A, Sagado HRN. (2012). Doxycycline hyclate: a review of properties, applications and analytical methods. Int J Life Sci Pharma Res 2:11–25
  • Koremacher WA. (2005). Foundation review: principles and applications of LC-MS in new drug discovery. Drug Discov Today 10:1357–67
  • Lazzarini M, Martin S, Mitkovski M. (2013). Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model. Glia 61:1084–100
  • Li F, Hsieh Y, Kang L, et al. (2009). MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections. Bioanalysis 1:299–307
  • Lin AJ, Castello NA, Lee G. (2014). In vivo optical signatures of neuronal death in a mouse model of Alzheimer's disease. Lasers Surg Med 46:27–33
  • Lindeberg JO, Mattsson R, Ebendal T. (2002). Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene. J Neurosci Res 68:248–53
  • Mcdonnell LA, Römpp A, Balluff B, et al. (2014). Discussion point: reporting guidelines for mass spectrometry imaging. Anal Bioanal Chem 407:2035–45
  • Mcewen AB, Henson CM, Wood SG. (2014). Quantitative whole-body autoradiography, LC-MS/MS and MALDI for drug-distribution studies in biological samples: the ultimate matrix trilogy. Bioanalysis 6:377–91
  • Meli DN, Coimbra RS, Erhart DG, et al. (2006). Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis. Infect Immun 74:3890–6
  • Pirman DA, Reich RF, Kiss AS, et al. (2012). Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard. Anal Chem 85:1081–9
  • Riond J, Riviere J. (1988). Pharmacology and toxicology of doxycycline. Vet Hum Toxicol 30:431–43
  • Riond J, Riviere J. (1990). Pharmacokinetics and metabolic inertness of doxycycline in young pigs. Am J Vet Res 51:1271–5
  • Shobo A, Bratkowska D, Baijnath S. (2015a). Tissue distribution of pretomanid in rat brain via mass spectrometry imaging. Xenobiotica. [Epub ahead of print]. DOI: 10.3109/00498254.2015.1067935
  • Shobo A, Bratkowska D, Baijanth S, et al. (2015b). Visualization of time-dependent distribution of rifampicin in rat brain using MALDI MSI and quantitative LCMS/MS. Assay Drug Dev Technol 13:277–84
  • Solon EG, Schweitzer A, Stoeckli M. (2010). Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. AAPS J 12:11–26
  • Suepaul S, Carrington C, Campbell M, et al. (2015). Antimicrobial susceptibility of Leptospira isolates from dogs and rats to 12 antimicrobial agents. Trop Biomed 32:1–10
  • Uckun OM, Alagoz F, Secer M, et al. (2015). Neuroprotective effects of tetracyclines on blunt head trauma: An experimental study on rats. J Neurosci Rural Pract 6:27
  • Végvári Á, Döme B. (2011). State-of-the-art MS technology applications in lung disease. Bioanalysis 3:2665–77
  • Widerøe M, Havnes MB, Morken TS, et al. (2012). Doxycycline treatment in a neonatal rat model of hypoxia–ischemia reduces cerebral tissue and white matter injury: a longitudinal magnetic resonance imaging study. Eur J Neurosci 36:2006–16
  • Yang F, Li Z, Shan Q, et al. (2014). Pharmacokinetics of doxycycline in tilapia (Oreochromis aureus× Oreochromis niloticus) after intravenous and oral administration. J Vet Pharmacol Ther 37:388–93
  • Yang F, Sun N, Zhao Z, Wang G, et al. (2015). Pharmacokinetics of doxycycline after a single intravenous, oral or intramuscular dose in Muscovy ducks (Cairina moschata). Br Poult Sci 56:137–42
  • Yrjänheikki J., Keinänen, R., Pellikka M, et al. (1998). Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci 95:15769–774

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