Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 6
677
Views
5
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Shedding light on minipig drug metabolism – elevated amide hydrolysis in vitro

, , , , , , , & show all
Pages 483-494 | Received 10 Jul 2015, Accepted 29 Aug 2015, Published online: 25 Sep 2015

References

  • Anzenbacherová E, Anzenbacher P, Svobodac Z, et al. (2003). Minipig as a model for drug metabolism in man: comparison of in vitro and in vivo metabolism of propafenone. Biomed Papers 147:155–9
  • Baggot JD. (1990). Pharmacokinetic–pharmacodynamic relationship. Ann Rech Vet 21:29S–40S
  • Bahar FG, Ohura K, Ogihara T, Imai T. (2012). Species difference of esterase expression and hydrolase activity in plasma. J Pharm Sci 101:3979–88
  • Benet LZ, Kroetz DL, Sheiner LB. (1996). Pharmacokinetics: the dynamics of drug absorption, distribution, and elimination. In: Molinoff PB, Ruddon RW, eds. Goodman and Gilman’s, the pharmacological basis of therapeutics. 9th ed. NewYork, USA: McGraw-Hill, 3–27
  • Benigni R, Passerini L. (2002). Carcinogenicity of the aromatic amines: from structure–activity relationships to mechanisms of action and risk assessment. Mutat Res/Rev Mutat Res 511:191–206
  • Bergeron JJM, Brenner MB, Thomas DY, Williams DB. (1994). Calnexin: a membrane-bound chaperone of the endoplasmic reticulum. TIBS 19:124–8
  • Bridges JW, French MR, Smith RL, Williams RT. (1970). The fate of benzoic acid in various species. Biochem J 118:47–51
  • Brüsehaber E, Böttcher D, Musidlowska-Persson A, et al. (2007). Identification of pig liver esterase variants by tandem mass spectroscopy analysis and their characterization. Appl Microbiol Biotechnol 76:853–9
  • Corcelli A, Saponetti MS, Zaccagnino P, et al. (2010). Mitochondria isolated in nearly isotonic KCl buffer: focus on cardiolipin and organelle morphology. Biochim Biophys Acta – Biomembr 1798:681–7
  • Crow JA, Borazjani A, Potter PM, Ross MK. (2007). Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol Appl Pharmacol 221:1–12
  • Crow JA, Bittles V, Herring KL, et al. (2012). Inhibition of recombinant human carboxylesterase 1 and 2. Toxicol Appl Pharmacol 258:145–50
  • Du Souich P, Erill S. (1976). Patterns of acetylation of procainamide and procainamide derived p aminobenzoic acid in man. Eur J Clin Pharmacol 10:283–7
  • Gamage N, Barnett A, Hempel N, et al. (2006). Human sulfotransferases and their role in chemical metabolism. Toxicol Sci 90:5–22
  • Godin SJ, Crow JA, Scollon EJ, et al. (2007). Identification of rat and human cytochrome P450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate. Drug Metab Dispos 35:1664–71
  • Helke KL, Swindle MM. (2013). Animal models of toxicology testing: the role of pigs. Expert Opin Drug Metab Toxicol 9:127–39
  • Hutt AJ, Caldwell J, Smith RL. (1986). The metabolism of aspirin in man: a population study. Xenobiotica 16:239–49
  • Hyatt JL, Stacy V, Wadkins RM, et al. (2005). Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the Dione Moiety. J Med Chem 48:5543–50
  • Jewell C, Ackermann C, Payne NA, et al. (2007a). Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver. Drug Metab Dispos 35:2015–22
  • Jewell J, Prusakiewicz JJ, Ackermann C, et al. (2007b). Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture. Toxicol Appl Pharmacol 225:221–8
  • Kawashima K, Hosoi K, Naruke T, et al. (1999). Aldehyde oxidase-dependent marked species difference in hepatic metabolism of the sedative-hypnotic, zaleplon, between monkeys and rats. Drug Metab Dispos 27:422–8
  • Marini S, Longo V, Mazzaccaro A, Gervasi PG. (1998). Xenobiotic-metabolizing enzymes in pig nasal and hepatic tissues. Xenobiotica 28:923–35
  • Martinez M, Amidon G, Clarke L, et al. (2002). Applying the biopharmaceutics classification system to veterinary pharmaceutical products. Part II. Physiological considerations. Adv Drug Deliv Rev 54:825–50
  • Miners JO, Mackenzie PI. (1991). Drug glucuronidation in humans. Pharmacol Ther 51:347–69
  • Miners JO, Smith PA, Sorich MJ, et al. (2004). Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches. Annu Rev Pharmacol Toxicol 44:1–25
  • Obach RS. (1999). Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Dispos 27:1350–9
  • Oesch F, Fabian E, Oesch-Bartlomowicz B, et al. (2007). Drug-metabolizing enzymes in the skin of man, rat, and pig. Drug Metab Rev 39:659–98
  • Patel DK, Notarianni LJ, Benset PN. (1990). Comparative metabolism of high doses of aspirin in man and rat. Xenobiotica 20:847–54
  • Patki KC, von Moltke LL, Greenblatt DJ. (2003). In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos 31:938–44
  • Paulson SK, Hribar JD, Liu NWK, et al. (1999). Metabolism and excretion of [14C]celecoxib in healthy male volunteers. Drug Metab Dispos 28:308–14
  • Perloff MD, von Moltke LL, Court MH, et al. (2000). Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. J Pharmacol Exp Ther 292:618–28
  • Prusakiewicz JJ, Ackermann C, Voorman R. (2006). Comparison of skin esterase activities from different species. Pharm Res 23:1517–24
  • Puccinelli E, Gervasi PG, Longo V. (2011). Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model. Curr Drug Metab 12:507–25
  • Quinney SK, Sanghani SP, Davis WI, et al. (2005). Hydrolysis of capecitabine to 5-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. J Pharmacol Exp Ther 313:1011–16
  • Skaanild MT. (2006). Porcine cytochrome P450 and metabolism. Curr Pharm Design 12:1421–7
  • Tabata T, Katoh M, Tokudome S, et al. (2004). Identification of the cytosolic carboxylesterase catalyzing the 5′-deoxy-5-fluorocytidine formation from capecitabine in human liver. Drug Metab Dispos 32:1103–10
  • Tang C, Shou M, Mei Q, et al. (2000). Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor. J Pharmacol Exp Ther 293:453–9
  • Taketani M, Shii M, Ohura K, et al. (2007). Carboxylesterase in the liver and small intestine of experimental animals and human. Life Sci 81:924–32
  • Toutain PL, Ferran A, Bousquet-Melou A. (2010). Species differences in pharmacokinetics and pharmacodynamics. Handb Exp Pharmacol 199:19–48
  • Venkatakrishnan K, Von Moltke LL, Greenblatt DJ. (2001). Human drug metabolism and the cytochromes P450: application and relevance of in vitro models. J Clin Pharmacol 41:1149–79
  • Vree TB, Beneken Kolmer EWJ, Peeters A. (1991). A comparison of the metabolism of four sulphonamides between humans and pigs. Vet Quart 13:236–40
  • Zhang J, Burnell JC, Dumaualand N, Bosron WF. (1999). Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1. J Pharmacol Exp Ther 290:314–18

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.