Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 6
704
Views
5
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Pharmacokinetic and pharmacodynamic interactions of aspirin with warfarin in beagle dogs

, , , , , , , , & show all
Pages 530-541 | Received 25 Jul 2015, Accepted 17 Sep 2015, Published online: 07 Nov 2015

References

  • Abdul MI, Jiang X, Williams KM, et al. (2010). Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin Pharmacol 69:508–15
  • Albers GW, Atwood JE, Hirsh J, et al. (1991). Stroke prevention in nonvalvular atrial fibrillation. Ann Int Med 115:727–36
  • Amlani S, Nadarajah T, Afzal R, et al. (2010). Mortality and morbidity following a major bleed in a registry population with acute ST elevation myocardial infarction. J Thromb Thrombolysis 30:434–40
  • Banfield C, O'Reilly R, Chan E, Rowland M. (1983). Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations. Br J Clin Pharmacol 16:669–75
  • Bellec G, Dreano Y, Lozach P, et al. (1996). Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Carcinogenesis 17:2029–34
  • Black DJ, Kunze KL, Wienkers LC, et al. (1996). Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies. Drug Metab Dispos 24:422–8
  • Bochner F, Siebert DM, Rodgers SE, et al. (1989). Measurement of aspirin concentrations in portal and systemic blood in pigs: effect on platelet aggregation, thromboxane and prostacyclin production. Thromb Haemost 61:211–16
  • Buckley NA, Dawson AH. (1992). Drug interactions with warfarin. Med J Aust 157:479–83
  • Cham BE, Ross-Lee L, Bochner F, Imhoff DM. (1980). Measurement and pharmacokinetics of acetylsalicylic acid by a novel high performance liquid chromatographic assay. Ther Drug Monit 2:365–72
  • Coudray C, Talla M, Martin S, et al. (1995). High-performance liquid chromatography-electrochemical determination of salicylate hydroxylation products as an in vivo marker of oxidative stress. Anal Biochem 227:101–11
  • Dentali F, Douketis JD, Lim W, Crowther M. (2007). Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med 167:117–24
  • Dupont I, Berthou F, Bodenez P, et al. (1999). Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. Drug Metab Dispos 27:322–6
  • Eikelboom JW, Quinlan DJ, O'Donnell M. (2009). Major bleeding, mortality, and efficacy of fondaparinux in venous thromboembolism prevention trials. Circulation 120:2006–11
  • Fiore LD, Ezekowitz MD, Brophy MT, et al. (2002). Department of veterans affairs cooperative studies program clinical trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: primary results of the CHAMP study. Circulation 105:557–63
  • Fiske WD, Connell JM, Benedek IH. (1995). Lack of pharmacokinetic interaction between aspirin and warfarin. Am J Ther 2:407–13
  • Gorelick PB. (2007). Combining aspirin with oral anticoagulant therapy: is this a safe and effective practice in patients with atrial fibrillation? Stroke 38:1652–4
  • Goren A, Liu X, Gupta S, et al. (2015). Warfarin and aspirin use for stroke prevention among patients with atrial fibrillation: The US national health and wellness survey. Am J Ther 22:248–56
  • Hart RG, Tonarelli SB, Pearce LA. (2005). Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas. Stroke 36:1588–93
  • Higgs GA, Salmon JA, Henderson B, Vane JR. (1987). Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proc Natl Acad Sci USA 84:1417–20
  • Hurlen M, Abdelnoor M, Smith P, et al. (2002). Warfarin, aspirin, or both after myocardial infarction. N Engl J Med 347:969–74
  • Jiang X, Williams KM, Liauw WS, et al. (2005). Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 59:425–32
  • Johnson SG, Rogers K, Delate T, Witt DM. (2008). Outcomes associated with combined antiplatelet and anticoagulant therapy. Chest 133:948–54
  • Johnson SG, Witt DM, Eddy TR, Delate T. (2007). Warfarin and antiplatelet combination use among commercially insured patients enrolled in an anticoagulation management service. Chest 131:1500–7
  • Kaminsky LS, Zhang ZY. (1997). Human P450 metabolism of warfarin. Pharmacol Ther 73:67–74
  • Krishna Kumar D, Gopal Shewade D, Parasuraman S, et al. (2013). Estimation of plasma levels of warfarin and 7-hydroxy warfarin by high performance liquid chromatography in patients receiving warfarin therapy. J Young Pharm 5:13–17
  • Leonards JR. (1962). Presence of acetylsalicylic acid in plasma following oral ingestion of aspirin. Proc Soc Exp Biol Med 110:304–8
  • Lewis HD Jr, Davis JW, Archibald DG, et al. (1983). Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study. N Engl J Med 309:396–403
  • Malhotra B, Alvey C, Gong J, et al. (2011). Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Br J Clin Pharmacol 72:257–62
  • Mirsen TR, Hachinski VC. (1988). Transient ischemic attacks and stroke. CMAJ 138:1099–105
  • Mohapatra R, Tran M, Gore JM, Spencer FA. (2005). A review of the oral direct thrombin inhibitor ximelagatran: not yet the end of the warfarin era. Am Heart J 150:19–26
  • O'Reilly RA, Trager WF, Motley CH, Howald W. (1980). Stereoselective interaction of phenylbutazone with [12C/13C]warfarin pseudoracemates in man. J Clin Invest 65:746–53
  • Palareti G, Legnani C. (1996). Warfarin withdrawal. Pharmacokinetic-pharmacodynamic considerations. Clin Pharmacokinet 30:300–13
  • Patrono C, Rodriguez LAG, Landolfi R, Baigent C. (2005). Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 353:2373–83
  • Rost S, Fregin A, Ivaskevicius V, et al. (2004). Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 427:537–41
  • Salem DN, O'Gara PT, Madias C, Pauker SG, American college of chest physicians. (2008). Valvular and structural heart disease: American college of chest physicians evidence-based clinical practice guidelines (8th Edition). Chest 133:593S–629S
  • Shen CL, Huang XH, Huang JH, et al. (2013). Development and validation of a RP-HPLC method for simultaneous determination of warfarin enantiomers, aspirin and salicylic acid in beagle plasma: application to pharmacokinetic study. Lat Am J Pharm 32:679–87
  • Toyoda K, Yasaka M, Iwade K, et al. (2008). Dual antithrombotic therapy increases severe bleeding events in patients with stroke and cardiovascular disease: a prospective, multicenter, observational study. Stroke 39:1740–5
  • van Es RF, Jonker JJ, Verheugt FW, et al. Antithrombotics in the secondary prevention of events in coronary thrombosis-2 research G. (2002). Aspirin and coumadin after acute coronary syndromes (the ASPECT-2 study): a randomised controlled trial. Lancet 360:109–13
  • Wittkowsky AK. (2003). Warfarin and other coumarin derivatives: pharmacokinetics, pharmacodynamics, and drug interactions. Semin Vasc Med 3:221–30

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.