References
- Aimo L. (2010). Low extracellular zinc increases neuronal oxidant production through NADPH oxidase and nitric oxide synthase activation. Free Radic Biol Med 48:1577–87
- Andreini C, Bertini I. (2012). A bioinformatics view of zinc enzymes. J Inorg Biochem 111:150–6
- Bell SG, Vallee BL. (2009). The metallothionein/thionein system: an oxidoreductive metabolic zinc link. Chembiochem 10:55–62
- Biaggio VS, Pérez Chaca MV, Valdéz SR, et al. (2010). Alteration in the expression of inflammatory parameters as a result of oxidative stress produced by moderate zinc deficiency in rat lung. Exp Lung Res 36:31–44
- Chae HZ, Kim HJ, Kang SW, et al. (1999). Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin. Diabetes Res Clin Pract 45:101–12
- Childs AC, Phaneuf SL, Dirks AJ, et al. (2002). Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio. Cancer Res 62:4592–8
- Eaton DL, Toal BF. (1982). Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol 66:134–42
- Haq F, Mahoney M, Koropatnick J. (2004). Signaling events for metallothionein induction. Mutat Res 533:211–26
- Formigari A, Irato P, Santon A. (2007). Zinc, antioxidant systems and metallothionein in metal mediated-apoptosis: biochemical and cytochemical aspects. Comp Biochem Physiol C Toxicol Pharmacol 146:443–59
- Fourquet S, Huang ME, D'Autreaux B, et al. (2008). The dual functions of thiol-based peroxidases in H2O2 scavenging and signaling. Antioxid Redox Signal 10:1565–76
- Fu Z, Guo J, Jing L, et al. (2010). Enhanced toxicity and ROS generation by doxorubicin in primary cultures of cardiomyocytes from neonatal metallothionein-I/II null mice. Toxicol In Vitro 24:1584–91
- Fukada T. (2011). Zinc homeostasis and signaling in health and diseases: zinc signaling. J Biol Inorg Chem 16:1123–34
- Gallagher BM, Phelan SA. (2007). Investigating transcriptional regulation of Prdx6 in mouse liver cells. Free Radic Biol Med 42:1270–7
- Ghoshal K, Jacob ST. (2000). Regulation of metallothionein gene expression. Prog Nucleic Acid Res Mol Biol 66:357–84
- Hall A, Karplus PA, Poole LB. (2009). Typical 2-Cys peroxiredoxins-structures, mechanisms and functions. FEBS J 276:2469–77
- Ho E, Ames BN. (2002). Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci USA 99:16770–5
- Iwahara S-i, Satoh H, Song D-X, et al. (1995). Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. Biochemistry 34:13398–406
- Jin DY, Chae HZ, Rhee SG, et al. (1997). Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. J Biol Chem 272:30952–61
- Jing L, Wu Y, Wu J, et al. (2011). Peroxiredoxins are involved in metallothionein protection from doxorubicin cardiotoxicity. Eur J Pharmacol 659:224–32
- Kaegi JH, Schaeffer A. (1988). Biochemistry of metallothionein. Biochemistry 27:8509–15
- Kalyanaraman B, Darley-Usmar V, Davies KJ, et al. (2012). Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med 52:1–6
- Kang YJ, Chen Y, Yu A, et al. (1997). Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J Clin Invest 100:1501–6
- Ke QM, Feng YB, Cheng B, et al. (2003). Protective effects of metallothionein induced by Zn∼(2+) on ischemia/reperfusion myocardium in isolated rat heart. Chin Pharmacol Bull 19:1274–6
- Kröncke KD, Fehsel K, Schmidt T. (1994). Nitric oxide destroys zinc-sulfur clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9. Biochem Biophys Res Commun 200:1105–10
- Kim CH, Kim JH, Lee J, et al. (2003). Zinc-induced NF-kappaB inhibition can be modulated by changes in the intracellular metallothionein level. Toxicol Appl Pharmacol 190:189–96
- Klassen RB, Crenshaw K, Kozyraki R, et al. (2004). Megalin mediates renal uptake of heavy metal metallothionein complexes. Am J Physiol Renal Physiol 287:F393–403
- Klein JB, Wang GW, Zhou Z, et al. (2002). Inhibition of tumor necrosis factor-alpha-dependent cardiomyocyte apoptosis by metallothionein. Cardiovasc Toxicol 2:209–18
- Kunisada K, Tone E, Negoro S, et al. (2002). Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation. Cardiovasc Res 53:936–43
- Li Q, Peng S, Sheng Z, et al. (2010). Ofloxacin induces oxidative damage to joint chondrocytes of juvenile rabbits: excessive production of reactive oxygen species, lipid peroxidation and DNA damage. Eur J Pharmacol 626:146–53
- Liu J-B, Wang Y-M, Peng S-Q, et al. (2007). Toxic effects of Fusarium mycotoxin butenolide on rat myocardium and primary culture of cardiac myocytes. Toxicon 50:357–64
- Mackenzie GG, Zago MP, Erlejman AG, et al. (2006). alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic Res 40:75–84
- Majsterek I, Sliwinski T, Poplawski T, et al. (2006). Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair. Mutat Res/Genet Toxicol Environ Mutagen 603:74–82
- Marques-Aleixo I, Santos-Alves E, Mariani D, et al. (2015). Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress. Mitochondrion 20:22–33
- Matsushima S, Ide T, Yamato M, et al. (2006). Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation 113:1779–86
- Merten KE, Feng W, Zhang L, et al. (2005). Modulation of cytochrome c oxidase-Va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity. J Pharmacol Exp Ther 315:1314–19
- Moffatt P, Denizeau F. (1996). Metallothionein in physiological and physiopathological processes. Drug Metab Rev 29:261–307
- Myers CE, McGuire WP, Liss RH, et al. (1977). Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response. Science 197:165–7
- Ohkawa H, Ohishi N, Kunio Y. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–8
- Oteiza PI. (2012). Zinc and the modulation of redox homeostasis. Free Radic Biol Med 53:1748–59
- Perkins A, Nelson KJ, Parsonage D, et al. (2015). Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci 40:435–45
- Poplawski T, Loba K, Pawlowska E, et al. (2010). Genotoxicity of urethane dimethacrylate, a tooth restoration component. Toxicol In Vitro 24:854–62
- Poynton RA, Hampton MB. (2013). Peroxiredoxins as biomarkers of oxidative stress. Biochim Biophys Acta 1840:906–12
- Ren J, Privratsky JR, Yang X, et al. (2008). Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. Crit Care Med 36:2106–16
- Rhee SG, Kang SW, Chang TS, et al. (2001). Peroxiredoxin, a novel family of peroxidases. IUBMB Life 52:35–41
- Rhee SG, Woo HA. (2011). Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones. Antioxid Redox Signal 15:781–94
- Sakurai A, Hara S, Okano N, et al. (1999). Regulatory role of metallothionein in NF-kappaB activation. FEBS Lett 455:55–8
- Shuai Y, Guo J, Dong Y, et al. (2011). Global gene expression profiles of MT knockout and wild-type mice in the condition of doxorubicin-induced cardiomyopathy. Toxicol Lett 200:77–87
- Shuai Y, Guo JB, Peng SQ, et al. (2007). Metallothionein protects against doxorubicin-induced cardiomyopathy through inhibition of superoxide generation and related nitrosative impairment. Toxicol Lett 170:66–74
- Singal PK. (1987). Subcellular effects of adriamycin in the heart: a concise review. J Mol Cell Cardiol 19:817–28
- Singal PK. (1998). Doxorubicin-induced cardiomyopathy. N Engl J Med 339:900–5
- Singh N, Stephens R. (1997). Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching. Mutat Res 383:167–75
- Siveski-Iliskovic N. (1994). Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 89:2829–35
- Siveski-Iliskovic N. (1995). Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect. Circulation 91:10–15
- Sun X, Zhou Z, Kang YJ. (2001). Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart. Cancer Res 61:3382–7
- Szewczyk B. (2013). Zinc homeostasis and neurodegenerative disorders. Front Aging Neurosci 5:158–64
- Uzzo RG. (2006). Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression. Carcinogenesis 27:1980–90
- Vasák M, Hasler DW. (2000). Metallothioneins: new functional and structural insights. Curr Opin Chem Biol 4:177–83
- Wang GW, Schuschke DA, Kang YJ. (1999). Metallothionein-overexpressing neonatal mouse cardiomyocytes are resistant to H2O2 toxicity. Am J Physiol 276:H167–75
- Wang GW, Kang Y. (1999). Inhibition of doxorubicin toxicity in cultured neonatal mouse cardiomyocytes with elevated metallothionein levels. J Pharmacol Exp Ther 288:938–44
- Watson WH, Yang X, Choi YE, et al. (2004). Thioredoxin and its role in toxicology. Toxicol Sci 78:3–14
- Wernerman J, Luo JL, Hammarqvist F. (1999). Glutathione status in critically-ill patients: possibility of modulation by antioxidants. Proc Nutr Soc 58:677–80
- Winterbourn CC, Hampton MB. (2008). Thiol chemistry and specificity in redox signaling. Free Radic Biol Med 45:549–61
- Wood ZA, Schröder E, Harris JR, et al. (2003). Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci 28:32–40
- Wozniak K, Szaflik JP, Zaras M, et al. (2009). DNA damage/repair and polymorphism of the hOGG1 gene in lymphocytes of AMD patients. J Biomed Biotechnol 2009:827562
- Xi L, Zhu SG, Daniel CH, et al. (2011). Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity. J Cell Mol Med 15:2512–24
- Yang HY, Wang YM, Peng SQ. (2010). Metallothionein-I/II null cardiomyocytes are sensitive to Fusarium mycotoxin butenolide-induced cytotoxicity and oxidative DNA damage. Toxicon 55:1291–6
- Yang KS. (2002). Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid. J Biol Chem 277:38029–36
- Zalewska M, Trefon J, Milnerowicz H. (2014). The role of metallothionein interactions with other proteins. Proteomics 14:1343–56