References
- Badertscher M, Bischofberger K, Munk ME, Pretsch E. (2001). A novel formalism to characterize the degree of unsaturation of organic molecules. J Chem Inf Comput Sci 41:889–93
- Boogaard PJ, van Sittert NJ. (1995). Biological monitoring of exposure to benzene: a comparison between S-phenylmercapturic acid, trans, trans-muconic acid, and phenol. Occup Environ Med 52:611–20
- Bucher JR. (1987). The toxicity of methyl isocyanate: where do we stand? Environ Health Perspect 72:197–8
- Cantin AM, North SL, Hubbard RC, Crystal RG. (1987). Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol 63:152–7
- Chipinda I, Stetson SJ, Depree GJ, et al. (2006). Kinetics and mechanistic studies of the hydrolysis of diisocyanate-derived bis-thiocarbamates of cysteine methyl ester. Chem Res Toxicol 19:341–50
- Davis MR, Kassahun K, Jochheim CM, et al. (1993). Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N′-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro. Chem Res Toxicol 6:376–83
- De Rooij BM, Commandeur JNM, Vermeulen NPE. (1998). Mercapturic acids as biomarkers of exposure to electrophilic chemicals: applications to environmental and industrial chemicals. Biomarkers 3:239–303
- Farrance I, Krauja VW, Dennis PM. (1975). The determination of gamma-glutamyl transpeptidase by reaction rate assay at 37 degrees C. Pathology 7:237–43
- Fuchs S, Valade P. (1951). Clinical and experimental study of some cases of poisoning by desmodur T (1-2-4 and 1-2-6 di-isocyanates of toluene). Arch Mal Prof 12:191–6
- Ghittori S, Maestri L, Imbriani M, et al. (1997). Urinary excretion of specific mercapturic acids in workers exposed to styrene. Am J Ind Med 31:636–44
- Gledhill A, Wake A, Hext P, et al. (2005). Absorption, distribution, metabolism and excretion of an inhalation dose of [14C] 4,4′-methylenediphenyl diisocyanate in the male rat. Xenobiotica 35:273–92
- Gross M, Whetzel NK, Folk JE. (1975). Alkyl isocyanates as active site-directed inactivators of guinea pig liver transglutaminase. J Biol Chem 250:7693–9
- Kennedy AL, Singh G, Alarie Y, Brown WE. (1993). Autoradiographic analyses of guinea pig airway tissues following inhalation exposure to 14C-labeled methyl isocyanate. Fundam Appl Toxicol 20:57–67
- Kennedy AL, Stock MF, Alarie Y, Brown WE. (1989). Uptake and distribution of 14C during and following inhalation exposure to radioactive toluene diisocyanate. Toxicol Appl Pharmacol 100:280–92
- Kennedy AL, Wilson TR, Stock MF, et al. (1994). Distribution and reactivity of inhaled 14C-labeled toluene diisocyanate (TDI) in rats. Arch Toxicol 68:434–43
- Kotapati S, Esades A, Matter B, et al. (2015). High throughput HPLC-ESI-MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: biomarkers of exposure and bioactivation. Chem Biol Interact 241:23–31
- Maestri L, Ghittori S, Imbriani M. (1997). Determination of specific mercapturic acids as an index of exposure to environmental benzene, toluene, and styrene. Ind Health 35:489–501
- Manini PR, Andreoli E, Bergamaschi G, et al. (2000). A new method for the analysis of styrene mercapturic acids by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom 14:2055–60
- Morris JB, Buckpitt AR. (2009). Upper respiratory tract uptake of naphthalene. Toxicol Sci 111:383–91
- Nassar AE. (2003). Online hydrogen–deuterium exchange and a tandem-quadrupole time-of-flight mass spectrometer coupled with liquid chromatography for metabolite identification in drug metabolism. J Chromatogr Sci 41:398–404
- Pauluhn J. (2014). Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level. Toxicology 319:10–22
- Pearson PG, Slatter JG, Rashed MS, et al. (1991). Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate. Chem Res Toxicol 4:436–44
- Pearson PG, Slatter JG, Rashed MS, et al. (1990). S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate. Biochem Biophys Res Commun 166:245–50
- Pellegrin V. (1983). Molecular formulas of organic compounds: the nitrogen rule and degree of unsaturation. J Chem Educ 60:626
- Redlich CA, Karol MH. (2002). Diisocyanate asthma: clinical aspects and immunopathogenesis. Int Immunopharmacol 2:213–24
- Reisser M, Schmidt BF, Brown WE. (2002). Synthesis, characterization, and solvolysis of mono- and bis-S-(glutathionyl) adducts of methylene-bis-(phenylisocyanate) (MDI). Chem Res Toxicol 15:1235–41
- Sanduja R, Ansari GA, Boor PJ. (1989). 3-Hydroxypropylmercapturic acid: a biologic marker of exposure to allylic and related compounds. J Appl Toxicol 9:235–8
- Sener A, Yardimci T. (2005). Activity determination, kinetic analyses and isoenzyme identification of gamma glutamyltransferase in human neutrophils. J Biochem Mol Biol 38:343–9
- Slatter JG, Rashed MS, Pearson PG, et al. (1991). Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities. Chem Res Toxicol 4:157–61
- Sterz K, Scherer G, Krumsiek J, et al. (2012). Identification and quantification of 1-hydroxybutene-2-yl mercapturic acid in human urine by UPLC–HILIC–MS/MS as a novel biomarker for 1,3-butadiene exposure. Chem Res Toxicol 25:1565–7
- Stone KL, DeAngelis R, LoPresti M, et al. (1998). Use of liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS) for routine identification of enzymatically digested proteins separated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis. Electrophoresis 19:1046–52
- Tarlo SM. (2008). Occupational exposures and adult asthma. Immunol Allergy Clin North Am 28:563–76, viii
- Wisnewski AV, Hettick JM, Siegel PD. (2011). Toluene diisocyanate reactivity with glutathione across a vapor/liquid interface and subsequent transcarbamoylation of human albumin. Chem Res Toxicol 24:1686–93
- Wisnewski AV, Liu J, Redlich CA. (2010). Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate. Anal Biochem 400:251–8
- Wisnewski AV, Liu J, Redlich CA. (2013a). Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure. Chem Biol Interact 205:38–45
- Wisnewski AV, Mhike M, Hettick JM, et al. (2013b). Hexamethylene diisocyanate (HDI) vapor reactivity with glutathione and subsequent transfer to human albumin. Toxicol in Vitro 27:662–71