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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 9
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS

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Pages 793-804 | Received 29 Oct 2015, Accepted 04 Dec 2015, Published online: 10 Jan 2016

References

  • Benassayag C, Perrot-Applanat M, Ferre F. (2002). Phytoestrogens as modulators of steroid action in target cells. J Chromatogr B Analyt Technol Biomed Life Sci 777:233–48
  • Beral V, Banks E, Reeves G, Appleby P. (1999). Use of HRT and the subsequent risk of cancer. J Epidemiol Biostat 4:191–215
  • Cao YF, Zhang YY, Li J, et al. (2010). CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes. Xenobiotica 40:38–47
  • Chien TH. (1957). Pharmacological action of Eucommia ulmoides, Oliv. Jpn J Pharmacol 6:122–37
  • Commission CP. (2010). Pharmacopoeia of the Peoples' Republic of China, volume I. Bejing, China: People's Medical Publishing House
  • Couse JF, Korach KS. (1999). Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20:358–417
  • Dai XP, Huang Q, Zhou BT, et al. (2013). Preparative isolation and purification of seven main antioxidants from Eucommia ulmoides Oliv. (Du-zhong) leaves using HSCCC guided by DPPH-HPLC experiment. Food Chem 139:563–70
  • Deng YT, Liao QF, Li SH, et al. (2008). Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple. J Chromatogr B Analyt Technol Biomed Life Sci 863:195–205
  • Deyama T, Nishibe S, Kitagawa S, et al. (1988). Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by lignan glucosides of Eucommia bark. Chem Pharm Bull 36:435–9
  • Du HY. (1996). Eucommia ulmoides Silviculture. Beijing, China: China Forestry Press
  • Du YT, Wu YF, Cao XL, et al. (2009). Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions. Biochimie 91:434–44
  • FDA. (2001). Guidance for industry: bioanalytical method validation. Rockville, Maryland: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine
  • Han H, Yang L, Xu Y, et al. (2011). Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom 25:3339–50
  • He XR, Wang JH, Li MX, et al. (2014). Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol 151:78–92
  • Hu FD, An J, Li W, et al. (2015). UPLC-MS/MS determination and gender-related pharmacokinetic study of five active ingredients in rat plasma after oral administration of Eucommia cortex extract. J Ethnopharmacol 169:145–55
  • Isiguro K, Yamaki M, Takagi S, et al. (1986). Studies on iridoid-related compounds. IV. Antitumor activity of iridoid aglycones. Chem Pharm Bull 34:2375–9
  • Jacquot Y, Rojas C, Refouvelet B, et al. (2003). Recent advances in the development of phytoestrogens and derivatives: an update of the promising perspectives in the prevention of postmenopausal diseases. Mini Rev Med Chem 3:387–400
  • Jin JS, Zhao YF, Nakamura N, et al. (2007). Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone. Biol Pharm Bull 30:904–11
  • Lafay S, Gil-Izquierdo A, Manach C, et al. (2006). Chlorogenic acid is absorbed in its intact form in the stomach of rats. J Nutr 136:1192–7
  • Lee MK, Kim MJ, Cho SY, et al. (2005). Hypoglycemic effect of Du-Zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 67:22–8
  • Li FD, Du HY. (2001). Eucommia ulmoides Oliv. Beijing, China: Chinese Medicine Press
  • Li WX, Guo JM, Tang YP, et al. (2012). Pharmacokinetic comparison of ferulic acid in normal and blood deficiency rats after oral administration of Angelica sinensis, Ligusticum chuanxiong and their combination. Int J Mol Sci 13:3584–97
  • Li Y, Sato T, Metori K, et al. (1998). The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliv. leaves on collagen synthesis. Biol Pharm Bull 21:1306–10
  • Liu YT, Hao HP, Xie HG, et al. (2010). Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats. Drug Metab Dispos 38:1779–84
  • Luo LF, Wu WH, Zhou YJ, et al. (2010). Antihypertensive effect of Eucommia ulmoides Oliv. extracts in spontaneously hypertensive rats. J Ethnopharmacol 129:238–43
  • Ma B, Zhang Q, Wang G, et al. (2011). Synthesis and pharmacokinetics of strontium fructose 1,6-diphosphate (Sr-FDP) as a potential anti-osteoporosis agent in intact and ovariectomized rats. J Inorg Biochem 105:563–8
  • Mikkola TS, Clarkson TB. (2002). Estrogen replacement therapy, atherosclerosis, and vascular function. Cardiovasc Res 53:605–19
  • Munson PL, Breese GR, Mueller RA. (1995). Principles of pharmacology: basic concepts and clinical applications. New York: Chapman and Hall
  • Oshima Y, Takata S, Hikino H, et al. (1988). Anticomplementary activity of the constituents of Eucommia ulmoides bark. J Ethnopharmacol 23:159–64
  • Rossouw JE, Anderson GL, Prentice RL, et al. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA. 288:321–33
  • Shi SY, Peng MJ, Zhang YP, Peng S. (2013). Combination of preparative HPLC and HSCCC methods to separate phosphodiesterase inhibitors from Eucommia ulmoides bark guided by ultrafiltration-based ligand screening. Anal Bioanal Chem 405:4213–23
  • Sih CJ, Ravikumar PR, Huang FC, et al. (1976). Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommia ulmoides, Oliver). J Am Chem Soc 98:5412–13
  • Suzuki Y, Kondo K, Ikeda Y, Umemura K. (2001). Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med 67:807–10
  • Takeshi D, Sanei N, Yoshihisa N. (2001). Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin 22:1057–70
  • Tavani A, Vecchia CL. (1999). The adverse effects of hormone replacement therapy. Drugs Aging 14:347–57
  • Turner RT, Riggs BL, Spelsberg TC. (1994). Skeletal effects of estrogen. Endocr Rev 15:275–300
  • Versi E, Harvey MA, Cardozo L, et al. (2001). Urogenital prolapse and atrophy at menopause: a prevalence study. Int Urogynecol J Pelvic Floor Dysfunct 12:107–10
  • Wang H, Li MC, Yang J, et al. (2011). Estrogenic properties of six compounds derived from Eucommia ulmoides Oliv. and their differing biological activity through estrogen receptors α and β. Food Chem 129:408–16
  • Wang JL, Liu EW, Zhang Y, et al. (2012). Validation of a HPLC-tandem MS/MS method for pharmacokinetics study of (+)-pinoresinol-di-β-d-glucopyranoside from Eucommia ulmoides Oliv extract in rats' plasma. J Ethnopharmacol 139:337–42
  • Xu W, Deng ZP, Guo H, Ling PX. (2012). A rapid and sensitive determination of aucubin in rat plasma by liquid chromatography-tandem mass spectrometry and its pharmacokinetic application. Biomed Chromatogr 26:1066–70
  • Xu Y, Zhang ZJ, Geng F, et al. (2010). Treatment with Qing’E, a kidney-invigorating Chinese herbal formula, antagonizes the estrogen decline in ovariectomized mice. Rejuvenation Res 13:479–88
  • Zhang AL, Ma Q, Gao JM, et al. (2001). Studies on bioactivities of chlorogenic acid and its analogues. Chin Tradit Herbal Drugs 32:173–6
  • Zhang R, Liu ZG, Li C, et al. (2009). Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats. Bone 45:553–9
  • Zheng J, Liu D, Zhao S, et al. (2012a). Enzymatic extraction and antibacterial activity of aucubin from Eucommia ulmoides leaves. Zhong Yao Cai 35:304–6
  • Zheng X, Huang XT, Li N, et al. (2012b). Determination of geniposidic acid in rat plasma by LC-MS/MS and its application to in vivo pharmacokinetic studies. J Chromatogr B 887888:138–42
  • Zhou YQ, Liang M, Li WZ, et al. (2009). Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid β-induced cytotoxicity. Environ Toxicol Pharmacol 28:342–9

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