References
- Beranic N, Gobec S, Rizner TL. (2011). Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact 191:227–33
- Beranic N, Brociz P, Brus B, et al. (2012). Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins. J Steroid Biochem Mol Biol 130:16–25
- Desta Z, Zhao X, Shin JG, Flockart DA. (2002). Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 41:913–58
- Jin Y, Mesaros C, Blair IA, Penning TM. (2011). Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1–AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway. Biochem J 437:53–61
- McGinnity DF, Parker AJ, Soars M, Riley RJ. (2000). Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metab Dispos 28:1327–34
- Mellon SH, Miller WL. (1989) Extraadrenal steroid 21-hydroxylation is not mediated by P450c21. J Clin Invest. 84:1497–502
- Mueck AO, Seeger H, Buehling KJ, (2009). Use of dydrogesterone in hormone replacement therapy. Maturitas 65S:S51–60
- Rižner TL, Penning TM. (2014). Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism. Steroids 79:49–63
- Strickler RC, Tobias B. (1982). 20-alpha-Hydroxysteroid dehydrogenase and 17 beta-estradiol dehydrogenase localize in cytosol of human term placenta. Am J Physiol 242:E178–83
- Schweppe KW. (2009). The place of dydrogesterone in the treatment of endometriosis and adenomyosis. Maturitas 65S:S23–7
- Summary of Product Characteristics of Duphaston 10mg Film-Coated Tablets. Available at: http://www.medicines.ie/medicine/5163/SPC/Duphaston [last accessed on 04 September 2015]
- Trivedi P, Selvaraj K, Mahapatra PD, et al. (2007). Effective postlaparoscopic treatment of endometriosis with dydrogesterone. Gynecol Endocrinol 23S1:73–6
- Van Amsterdam PH, Overmars H, Scherpenisse PM, De Bree H. (1980). Dydrogesterone: metabolism in man. Eur J Drug Metab Pharmacokinet 5:173–84
- Wiebe JP. (2006). Progesterone metabolites in breast cancer. Endocr Relat Cancer 13:717–38
- Yamazaki H, Shimada T. (1997). Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys 346:161–9