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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 11
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs

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Pages 1017-1025 | Received 14 Dec 2015, Accepted 17 Jan 2016, Published online: 17 Feb 2016

References

  • Amagase H, Petesch BL, Matsuura H, et al. (2001). Intake of garlic and its bioactive components. J Nutr 131:955S–62S
  • Amano H, Kazamori D, Itoh K, et al. (2015). Metabolism, excretion, and pharmacokinetics of S-allyl-l-cysteine in rats and dogs. Drug Metab Dispos 43:749–55
  • Budoff MJ, Ahmadi N, Gul KM, et al. (2009). Aged garlic extract supplemented with B vitamins, folic acid and l-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med 49:101–7
  • Chu Q, Lee DT, Tsao SW, et al. (2007). S-Allylcysteine, a water-soluble garlic derivative, suppresses the growth of a human androgen-independent prostate cancer xenograft, CWR22R, under in vivo conditions. BJU Int 99:925–32
  • Chuah SC, Moore PK, Zhu YZ. (2007). S-Allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway. Am J Physiol Heart Circ Physiol 293:H2693–701
  • Cruz C, Correa-Rotter R, Sánchez-González DJ, et al. (2007). Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats. Am J Physiol Renal Physiol 293:F1691–8
  • Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharm Res 10:1093–5
  • Dekant W, Lash LH, Anders MW. (1988). Fate of glutathione conjugates and bioactivation of cysteine S-conjugates by cysteine conjugate β-lyase. In: Sies H, Ketterer B, eds. Glutathione conjugation: mechanisms and biological significance. London: Academic Press, pp. 415–47
  • Hinchman CA, Ballatori N. (1994). Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process. J Toxicol Environ Health 41:387–409
  • Horner WH, Kuchinskas EJ. (1959). Metabolism of methyl-labeled S-methylcysteine in the rat. J Biol Chem 234:2935–7
  • Hsu CC, Yen HF, Yin MC, et al. (2004). Five cysteine-containing compounds delay diabetic deterioration in Balb/cA mice. J Nutr 134:3245–9
  • Lawson LD, Wang ZJ. (1995). Changes in the organosulfur compounds released from garlic during aging in water, dilute ethanol, or dilute acetic acid. J Toxicol 14:214
  • Mitchell SC, Smith RL, Waring RH, et al. (1984). The metabolism of S-methyl-l-cysteine in man. Xenobiotica 14:767–79
  • Nantz MP, Rowe CA, Muller CE, et al. (2012). Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention. Clin Nutr 31:337–44
  • Nishikawa-Ogawa M, Wanibuchi H, Morimura K, et al. (2006). N-Acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage. Carcinogenesis 27:982–8
  • Obach RS. (1999). Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Dispos 27:1350–9
  • Ried K, Frank OR, Stocks NP. (2010). Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas 67:144–50
  • Silbernagl S, Foulkes EC, Deetjen P. (1975). Renal transport of amino acids. Rev Physiol Biochem Pharmacol 74:105–67
  • Sklan NM, Barnsley EA. (1968). The metabolism of S-methyl-L-cysteine. Biochem J 107:217–23
  • Steiner M, Khan AH, Holbert D, et al. (1996). A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 64:866–70
  • Tabata K, Yamaoka K, Kaibara A, et al. (1999). Moment analysis program available on Microsoft Excel. Xenobio Metabol Dispos 14:286–93
  • Wassef R, Haenold R, Hansel A, et al. (2007). Methionine sulfoxide reductase A and a dietary supplement S-methyl-l-cysteine prevent Parkinson’s-like symptoms. J Neurosci 27:12808–16

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