Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

Ryan H. TakahashiDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA, Correspondence[email protected]

Shuguang MaDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

Qin YueDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

Heasook Kim-KangXenoBiotic Laboratories, Inc, Plainsboro, NJ, USA,

Yijun YiXenoBiotic Laboratories, Inc, Plainsboro, NJ, USA,

Justin LyDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

Jason W. BoggsDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

Alec FettesPharma Technical Development, Process Research & Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland, and

Andrew McClorySmall Molecule Process Chemistry, Genentech, Inc., South San Francisco, CA, USA

Yuzhong DengDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

Cornelis E. C. A. HopDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

S. Cyrus KhojastehDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

Edna F. ChooDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA,

References