Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 2
296
Views
12
CrossRef citations to date
0
Altmetric
Xenobiotic Transporters

Saikosaponin A, an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cells and HepG2/ADM cells

&
Pages 176-184 | Received 12 Feb 2016, Accepted 24 Mar 2016, Published online: 28 Apr 2016

References

  • Abdallah HM, Al-Abd AM, El-Dine RS, El-Halawany AM. (2015). P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: a review. J Adv Res 6:45–62
  • Aller SG, Yu J, Ward A, et al. (2009). Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 323:1718–22
  • Ashour ML, Wink M. (2011). Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action. J Pharm Pharmacol 63:305–21
  • Cai J, Chen S, Zhang W, et al. (2014). Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2. Phytomedicine 21:984–91
  • Chen JC, Chang NW, Chung JG, Chen KC. (2003). Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells. Am J Chin Med 31:363–77
  • Chen JX, Ji B, Lu ZL, Hu LS. (2005). Effects of chai hu (radix burpleuri) containing formulation on plasma beta-endorphin, epinephrine and dopamine on patients. Am J Chin Med 33:737–45
  • Chen T, Wang C, Liu Q, et al. (2015). Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway. Cancer Biol Ther 16:106–14
  • Chen Y, Zhao Y, Wang C, et al. (2012). Inhibition of p38 MAPK diminishes doxorubicin -induced drug resistance associated with P-glycoprotein in human leukemia K562 cells. Med Sci Monit 18:BR383–8
  • Denisov EV, Dulesova AY, Cherdyntseva NV, et al. (2014). The phenomenon of multi-drug resistance in the treatment of malignant tumors. Exp Oncol 36:144–56
  • Germano S, O'Driscoll L. (2009). Breast cancer: understanding sensitivity and resistance to chemotherapy and targeted therapies to aid in personalised medicine. Curr Cancer Drug Targets 9:398–418
  • He D, Wang H, Xu L, et al. (2016). Saikosaponin – a attenuates oxidized LDL uptake and prompts cholesterol efflux in THP-1 cells. J Cardiovasc Pharmacol 2016. [Epub ahead of print]. doi: 10.1097/FJC.0000000000000373
  • Honjo K, Takahashi KA, Mazda O, et al. (2010). MDR1a/1b gene silencing enhances drug sensitivity in rat fibroblast-like synoviocytes. J Gene Med 12:219–27
  • Hu T, To KK, Wang L, et al. (2014). Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of salvia miltiorrhiza. Phytomedicine 21:1264–72
  • Jin W, Lu Y, Li Q, et al. (2014). Down-regulation of the P-glycoprotein relevant for multidrug resistance by intracellular acidification through the crosstalk of MAPK signaling pathways. Int J Biochem Cell Biol 54:111–21
  • Kim BM, Hong SH. (2011). Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. Apoptosis 16:184–97
  • Kim HG, Hien TT, Han EH, et al. (2011). Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation. Br J Pharmacol 162:1096–108
  • Kim SO, Park JY, Jeon SY, et al. (2015). Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways. Int J Mol Med 35:1126–32
  • Kort A, Durmus S, Sparidans RW, et al. (2015). Brain and testis accumulation of regorafenib is restricted by breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1). Pharm Res 32:2205–16
  • Lee CH. (2010). Reversing agents for ATP-binding cassette drug transporters. Meth Mol Biol 596:325–40
  • Li XQ, Gao QT, Chen XH, Bi KS. (2005). High performance liquid chromatographic assay of saikosaponins from radix Bupleuri in China. Biol Pharm Bull 28:1736–42
  • Luqmani YA. (2005). Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract 14:35–48
  • Qi FH, Wang ZX, Cai PP, et al. (2013). Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection. Drug Discov Ther 7:212–24
  • Ramesh R, Kozhaya L, McKevitt K, et al. (2014). Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med 211:89–104
  • Rigalli JP, Ciriaci N, Arias A, et al. (2015). Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity. PLoS One 10:e0119502
  • Sharom FJ. (2014). Complex interplay between the P-glycoprotein multidrug efflux pump and the membrane: its role in modulating protein function. Front Oncol 4:41
  • Shi Y, Wang SY, Yao M, et al. (2015). Chemosensitization of HepG2 cells by suppression of NF-κB/p65 gene transcription with specific-siRNA. World J Gastroenterol 21:12814–21
  • Tran TP, Kim HG, Choi JH, et al. (2013). Reversal of P-glycoprotein-mediated multidrug resistance is induced by mollugin in MCF-7/adriamycin cells. Phytomedicine 20:622–31
  • Tsai YJ, Chen IL, Horng LY, Wu RT. (2002). Induction of differentiation in rat C6 glioma cells with saikosaponins. Phytother Res 16:117–21
  • Vadlapatla RK, Vadlapudi AD, Pal D, Mitra AK. (2013). Mechanisms of drug resistance in cancer chemotherapy: coordinated role and regulation of efflux transportersand metabolizing enzymes. Curr Pharm Des 19:7126–40
  • Volpe DA. (2011). Drug-permeability and transporter assays in caco-2 and MDCK cell lines. Future Med Chem 3:2063–77
  • Wang C, Zhu M, Xia W, et al. (2012). Meta-analysis of traditional Chinese medicine in treating functional dyspepsia of liver-stomach disharmony syndrome. J Tradit Chin Med 32:515–22
  • Wang SF, Chou YC, Mazumder N, et al. (2013). 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochem Pharmacol 86:548–60
  • Wong VK, Zhang MM, Zhou H, et al. (2013). Saikosaponin-d enhances the anticancer potency of TNF-α via overcoming its undesirable response of activating NF-Kappa B signalling in cancer cells. Evid Based Complement Alternat Med 2013:745295
  • Wu GC, Wu H, Fan LY, Pan HF. (2011). Saikosaponins: a potential treatment option for systemic lupus erythematosus. Ir J Med Sci 180:259–61
  • Wu Q, Yang Z, Nie Y, et al. (2014). Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches. Cancer Lett 347:159–66
  • Wu WS, Hsu HY. (2001). Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells. Biochem Biophys Res Commun 285:183–7
  • Xue P, Yang X, Liu Y, et al. (2014). A novel compound RY10-4 downregulates P-glycoprotein expression and reverses multidrug-resistant phenotype in human breast cancer MCF-7/ADR cells. Biomed Pharmacother 68:1049–56
  • Yun M, Lee D, Park MN, et al. (2015). Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling. Cell Physiol Biochem 35:1821–30
  • Zhang K, Wang X, Wang H. (2014). Effect and mechanism of Src tyrosine kinase inhibitor sunitinib on the drug-resistance reversal of human A549/DDP cisplatin-resistant lung cancer cell line. Mol Med Rep 10:2065–72
  • Zhang ZJ, Tan QR, Tong Y, et al. (2011). An epidemiological study of concomitant use of Chinese medicine and antipsychotics in schizophrenic patients: implication for herb-drug interaction. PLoS One 6:e17239
  • Zhao R, Liu L, Wang Y, Xiao Z. (2014). Vinegar-baked Radix Bupleuri modulates the cell membrane constituents and inhibits the P-gp activity in rat hepatocytes. BMC Complement Altern Med 14:357
  • Zhou C, Liu W, He W, et al. (2015). Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways. Int Immunopharmacol 25:49–54

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.