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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 9
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Original Article

Critical evaluation of 7-ethoxycoumarin O-deethylase activity measurement in intact isolated rat hepatocytes

V. Rogiers Department of Toxicology and Department of Anesthesiology, Free University Brussels, Laarbeeklaan, 103, B-1090, Brussels, Belgium
,
L. Adriaenssens Department of Toxicology and Department of Anesthesiology, Free University Brussels, Laarbeeklaan, 103, B-1090, Brussels, Belgium
,
Y. Vandenberghe Department of Toxicology and Department of Anesthesiology, Free University Brussels, Laarbeeklaan, 103, B-1090, Brussels, Belgium
,
E. Gepts Department of Toxicology and Department of Anesthesiology, Free University Brussels, Laarbeeklaan, 103, B-1090, Brussels, Belgium
,
A. Callaerts Department of Toxicology and Department of Anesthesiology, Free University Brussels, Laarbeeklaan, 103, B-1090, Brussels, Belgium
&
A. Vercruysse Department of Toxicology and Department of Anesthesiology, Free University Brussels, Laarbeeklaan, 103, B-1090, Brussels, Belgium
Pages 817-826 | Received 10 Oct 1985, Published online: 30 Sep 2009

References

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  • Boobis A. R., Kahn G. C., Whyte C., Brodie M. J., Davies D. S. Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions. Biochemical Pharmacology 1981; 30: 2451–2456
  • De Graeve J., Kremers P., Frankinet C., Gielen J. A new highly sensitive assay for ethoxycoumarin deethylase in cultured hepatocytes. Analytical Biochemistry 1980; 104: 419–424
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  • Rogiers V., Vandenberghe Y., Vercruysse A. Inhibition of gluconeogenesis by sodium valproate and its metabolites in isolated rat hepatocytes. Xenobiotica 1985; 15: 759–765
  • Siegel S. Nonparametric Statistics for the Behavioral Sciences, S. Siegel. McGraw-Hill Kogakusha, Tokyo 1956; 116
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  • Ullrich V., Weber P. The O-dealkylation of 7-ethoxycoumarin by liver microsomes. Hoppe-Zeyler's Zeitschrift Physiologische Chemie 1972; 335: 1171–1177

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