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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 12
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Original Article

The metabolism of [14C]N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) in laboratory animals

I. D. Wilson Department of Safety of Medicines, ICI Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
K. V. Watson Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton, Milton Keynes, Bucks, MK7 7AJ, UK
,
J. Troke Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton, Milton Keynes, Bucks, MK7 7AJ, UK
,
H. P. A. Illing Health and Safety Executive (EMAS C4), Baynards House, Chepstow Place, London, W2 4TF, UK
,
J. M. Fromson Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton, Milton Keynes, Bucks, MK7 7AJ, UK
&
E. Schraven Cassella AG, 6000, Frankfurt Main 61, FR Germany
Pages 1117-1128 | Received 25 Sep 1985, Published online: 30 Sep 2009

References

  • Ahmed A. E., Trieff N. M. Aliphatic nitriles; metabolism and toxicity. Progress in Drug Metabolism, Voi. 7, J. M. Bridges, L. F. Chasseau. John Wiley, London 1983; 229–294
  • Ashai Y., Shinozaki K., Nagoaka M. Chemical and kinetic study on stabilities of 3-morpholinosydnonimine and its N-ethoxycarbonyl derivative. Chemical and Pharmaceutical Bulletin 1971; 19: 1079–1088
  • Chatfield D. M. Disposition and metabolism of some nitrofurylthiazoles possessing antiparasitic activity. Xenobiotica 1976; 6: 509–520
  • Dell D., Chamberlain J. Determination of molsidomine in plasma by high performance liquid chromatography. Journal of Chromatography 1978; 146: 465–472
  • Fromson J. M., Illing H. P. A., Ings R. M. J., Johnson K. I., Johnson P., Ostrowski J., Schraven E., Steward A. Absorption and disposition of 14C-molsidomine in laboratory animals. Arzneimittel-Forschung 1981; 31: 337–345
  • Hayasht T. Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (Emorfazone).V.l) Effect of inducer pretreatment on oxygenation of the morpholine moiety in guinea pigs. Chemical and Pharmaceutical Bulletin 1982; 30: 3748–3756
  • Johnson P., Rising P. A., Rising T. J. Liquid scintillation counting of biological samples using extended standardization and automatic data processing. Liquid Scintillation Counting, Vol. 2, M. A. Crook, P. Johnson, B. Scales. Heyden, London 1972; 267–277
  • Masuda K., Tonga T., Hayashi N. Synthesis of 3-morpholino-N-ethoxycarbonyl- sydnonimine-5-14C (Sin-10-14C). Journal of Labelled Compounds 1975; 11: 301–304
  • Tanayama S., Nakai Y., Fujita T., Suzuoki Z., Imashiro Y., Masuda K. Biotransformation of molsidomine (N-ethoxycarbonyl-3-morpholinosydnonimine), a new antianginal agent in rats. Xenobiotica 1974; 4: 175–191

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