Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 4
10
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Metabolism of nipradilol by liver homogenates from different species. I. Comparative studies on the denitration of nipradilol and other organic nitrates

, , &
Pages 307-315 | Received 19 Jul 1985, Published online: 22 Sep 2008

References

  • de Duve C., Pressman B.C., Gianetto R., Wattiaux R., Appelmans F. Tissue fractionation studies 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochemical Journal 1955; 60: 604–617
  • Ellman G.L. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics 1959; 82: 70–77
  • Habig W.H., Keen J.H., Jakoby W.B. Glutathione S-transferase in the formation of cyanide from organic thiocyanates and as an organic nitrate reductase. Biochemical and Biophysical Research Communications 1975; 64: 501–506
  • Habig W.H., Jakoby W.B. Assays for differentiation of glutathione S-transferases. Methods in Enzymology, W.B. Jakoby. Academic Press. 1981; 77: 398–405
  • Kawashima K., Watanabe T., Sokabe H. Pharmacodynamic and pharmacokinetic studies on prizidilol and nipradilol (K-351), antihypertensive drugs with combined vasodilator and β-adrenoceptor blocking actions, in rabbits. Japanese Journal of Pharmacology 1984; 36: 519–526
  • Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Needleman P. Organic nitrate metabolism. Annual Reviews in Pharmacology and Toxicology 1976; 16: 81–93
  • Needleman P., Hunter F.E., Jr. The transformation of glyceryl trinitrate and other nitrates by glutathione-organic nitrate reductase. Molecular Pharmacology 1965; 1: 77–86
  • Needleman P., Krantz J.C., Jr. The biotransformation of nitroglycerin. Biochemical Pharmacology 1965; 14: 1225–1230
  • Sasame H.A., Boyd M.R. Paradoxical effects of cobaltous chloride and salts of other divalent metals on tissue levels of reduced glutathione and microsomal mixed-function oxidase components. Journal of Pharmacology and Experimental Therapeutics 1978; 205: 718–724
  • Sedgwick B., Hubscher G. Metabolism of phospholipids IX. Phosphatidate phospho-hydrolase in rat liver. Biochimica et Biophysica Acta 1965; 106: 63–77
  • Shechter H., Gruener N., Shuval H.I. A micromethod for the determination of nitrite in blood. Anaiytica Chimica Acta 1972; 60: 93–99
  • Yoshimura M., Kojima J., Itoh T., Suzuki J. Pharmacokinetics of nipradilol (K-351), a new hypertensive agent. I. Studies on interspecies variation in laboratory animals. Journal of Pharmacobio-Dynamics 1985; 8: 738–750
  • Uchida Y., Nakamura M., Shimizu S., Shirasawa Y., Fujii M. Vasoactive and β-adrenoceptor blocking properties of 3,4-dihydro-8-(2-hydroxy-3-isopropylamino) propoxy-3-nitroxy-2H-1-benzopyran (K-351), a new antihypertensive agent. Archives Internationales de Pharmacodynamie et de Therapie 1983; 262: 132–149

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.