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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 7
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Original Article

N-Sulphoconjugation of alicyclic, alkyl- and aryl-amines in vivo and in vitro

K. Iwasaki Department of Pharmacokinetics and Drug Metabolism, Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, 2-Chome, Kashima, Yodogawa-ku, Osaka, 532, Japan
,
T. Shiraga Department of Pharmacokinetics and Drug Metabolism, Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, 2-Chome, Kashima, Yodogawa-ku, Osaka, 532, Japan
,
K. Noda Department of Pharmacokinetics and Drug Metabolism, Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, 2-Chome, Kashima, Yodogawa-ku, Osaka, 532, Japan
,
K. Tada Department of Pharmacokinetics and Drug Metabolism, Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, 2-Chome, Kashima, Yodogawa-ku, Osaka, 532, Japan
&
H. Noguchi Department of Pharmacokinetics and Drug Metabolism, Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, 2-Chome, Kashima, Yodogawa-ku, Osaka, 532, Japan
Pages 651-659 | Received 06 Aug 1985, Published online: 30 Sep 2009

References

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  • Caldwell J. Conjugation reactions of nitrogen centers. Metabolic Basis of Detoxication, W.B. Jakoby, J.R. Bend, J. Caldwell. Academic Press, New York 1982; 291–306
  • Damani L.A. Oxidation at nitrogen centers. Metabolic Basis of Detoxication, W.B. Jakoby, J.R. Bend, J. Caldwell. Academic Press, New York 1982; 127–149
  • DeMeio R.H. Sulfate activation and transfer. Metabolic Pathways, 3rd ed., D.M. Greenberg. Academic Press, New York 1975; Vol. 7: 287–358
  • Iwasaki K., Shiraga T., Noda K., Tada K., Noguchi H. Terminal N-sulphoconjugation of an alicyclic amine (piperazine), identified as a new metabolite of tiaramide in mouse and rat. Xenobiotica 1983a; 13: 273–278
  • Iwasaki K., Shiraga T., Noda K., Tada K., Noguchi H. Metabolism of tiaramide in vitro. III. Sulphoconjugation of alicyclic amine and alcoholic hydroxyl group by hepatic 105000g supernatants. Xenobiotica 1983b; 13: 565–574
  • Lindeke B., Cho A.K. N-Dealkylation and deamination. Metabolic Basis of Detoxication, W.B. Jakoby, J.R. Bend, J. Caldwell. Academic Press, New York 1982; 105–126
  • Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Noguichi H., Iwasaki K. Metabolism of tiaramide in vitro. II. Oxidation of piperazineethanol group in tiaramide by 105 000g supernatants from monkey and rat liver. Xenobiotica 1982; 12: 499–508
  • Noguchi H., Tada K., Iwasaki K. Urinary metabolite profiles of tiaramide in man and in some animal species. Xenobiotica 1982; 12: 211–220
  • Prosser C.I., Roy A.B. On the existance of arylamine sulphotransferase activity. Biochemical Pharmacology 1982; 31: 2675–2676
  • Roy A.B. Sulphate conjugation enzymes. Handbook of Experimental Pharmacology 1971; 28: 536–563
  • Sekura R.D. Adenosine 3′-phosphate 5′-phosphosulfate. Methods in Enzymology 1981; 77: 413–415
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