Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 3
56
Views
38
CrossRef citations to date
0
Altmetric
Original Article

Extrapolation from animals to man: predictions, pitfalls and perspectives

Pages 255-265 | Published online: 30 Sep 2009

References

  • Alván G., Jönssen M., Sundwall A., Vessman J. First pass conjugation and enterohepatic recycling of oxazepam in dogs; intravenous tolerance of oxazepam in propylene glycol. Acta Pharmacologica et Toxicologica 1977; 40(Suppl. I)16–27
  • Acebutolol. The Medical Letter, Drugs and Therapeutics 1985; 27(691)58–60, Anon.
  • Ariëns E. J. Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology. European Journal of Clinical Pharmacology 1984; 26: 663–668
  • Caldwell J. The current status of attempts to predict species differences in drug metabolism. Drug Metabolism Reviews 1981; 12: 221–237
  • Duggan D. E., Kwan K. C. Enterohepatic recirculation of drugs as a determinant of therapeutic ratio. Drug Metabolism Reviews 1979; 9: 21–41
  • Khan M. A. Minipig: Advantages and disadvantages as a model in toxicity testing. Journal of the American College of Toxicology 1984; 3: 337–342
  • Lee E. J. D., William K., Day R., Graham G., Champion D. Stereoselective disposition of ibuprofen enantiomers in man. British Journal of Clinical Pharmacology 1985; 19: 669–674
  • Lewis A. J., Carlson R. P., Chang J., Gilman S. C., Nielsen S., Rosenthale M. E., Janssen F. W., Ruelius H. W. The pharmacological profile of oxaprozin, an antiinflammatory and analgesic agent with low gastrointestinal toxicity. Current Therapeutic Research 1983; 34: 777–794
  • Lewis A. J., Janssen F. W., Bonney S. L., Ruelius H. W., Hubsher J. A., Walker B. R. Oxaprozin. Anti-inflammatory and anti-rheumatic drugs, K. D. Rainsford. CRC Press, Boca Raton 1985; Vol. II: 189–208
  • Odar-Cederlöf I., Vessman J., Alván G., Sjöquist F. Oxazepam disposition in uremic patients. Acta Pharmacologica et Toxicologica 1977; 40(Suppl. I)52–62
  • Parke D. V. The Biochemistry of Foreign Compounds. Pergamon, Oxford 1968; 129
  • Quon C. Y., Stampfli H. F. Biochemical properties of blood esmolol esterases. Drug Metabolism and Disposition 1985; 13: 420–424
  • Ruelius H. W. Interaction of drug metabolism with the other elements of drug safety evaluation. Drug Metabolism Reviews 1975; 4: 115–133
  • Ruelius H. W., Young E. M., Kirkman S. K., Schillings R. T., Sisenwine S. F., Janssen F. W. Biological fate of acyl glucuronides in the rat: The role of rearrangement, intestinal enzymes and reabsorption. Biochemical Pharmacology 1985; 34: 451–452
  • Sisenwine S. F., Tio C. O., Ruelius H. W. Metabolic disposition of ciramodol in rhesus monkeys and rats. Drug Metabolism and Disposition 1982; 10: 161–167
  • Smith R. L. The Excretory Function of Bile. Chapman and Hall, London 1973
  • Von Wartburg B. R., Voges R., Sieber W. Computer assisted metabolism prediction: problems, shortcomings and results. Ninth European Workshop on Drug Metabolism. NancyFrance 1984; 6, Abstract no. S2
  • Walle T. Stereochemistry of the in vivo disposition and metabolism of propranolol in dog and man using deuterium-labeled pseudoracemates. Drug Metabolism and Disposition 1985; 13: 279–282
  • Wilson B. K., Thompson J. A. Glucuronidation of propranolol by dog liver microsomes: Effects of enantiomeric inhibition and detergent treatment on stereoselectivity. Drug Metabolism and Disposition 1984; 12: 161–164
  • Winkle R. A., Meffin P. J., Ricks W. B., Harrison D. C. Acebutolol metabolite plasma concentration during chronic oral therapy. British Journal of Clinical Pharmacology 1977; 4: 519–522
  • Wipke W. T., Ouchi G. I., Chou J. T. Computer-assisted prediction of metabolism. Structure Activity Correlation as a Predictive Tool in Toxicology, L. Golberg. Hemisphere Publications, Washington, DC 1983; 151–69
  • Yost G. S., Johnson L. P., Pallante S., Colvin M., Fenselau C. Glucuronyltransferase stereoselectivity. Federation Proceedings 1981; 40: 650

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.