Use of stable isotopes in the elucidation of drug biotransformation processes

References

• Baillie T. A. The use of stable isotopes in phamacological research. Pharmacological Reviews 1981; 33: 81–132
   PubMed Web of Science ®Google Scholar
• Baillie T. A., Rettenmeier A. W., Peterson L. A., Castagnoli N., Jr. Stable isotopes in drug metabolism and disposition. Ann. Reports in Medicinal Chemistry 1984; 19: 273–284
   Google Scholar
• Branfman A. R., McComich M. F., Bruni R. J., Callahan M. M., Robertson R., Yesair D. W. Characterization of diaminouracil metabolites of caffiene in human urine. Drug Metabolism and Disposition 1983; 11: 206–210
   PubMed Web of Science ®Google Scholar
• Brazelton W. E., Jr., Orr J. C., Engel L. L. The twin ion technique for the detection of metabolites by gas chromatography-mass spectrometry: Intermediates in estrogen biosynthesis. Analytical Biochemistry 1973; 33: 64–85
   Google Scholar
• Chaudhari N. K., Servando O. A., Mannielo M. J., Luders R. C., Chao D. K., Bartlett M. F. Metabolism of tripelennamine in man. Drug Metabolism and Disposition 1976; 4: 372–378
   PubMedGoogle Scholar
• Fischer L. J., Thies R. L., Charkowski D., Donham K. J. Formation and urinary excretion of cyproheptadine glucuronide in monkeys, chimpanzees and humans. Drug Metabolism and Disposition 1980; 8: 422–424
   PubMed Web of Science ®Google Scholar
• Fischer C., Meese C. O., Klotz U. A stable isotope method for the quantification of N-acetyl-5-aminosalicylic acid in plasma and urine. Biomedical Mass Spectrometry 1984; 11: 539–544
   PubMedGoogle Scholar
• Goromaru T., Furuta T., Baba S., Noda A., Iguchi S. Metabolic studies of aminopyrine in rat and man by using stable isotope tracer techniques. Chemistry Pharmacology Bulletin 1981; 29: 1724–1729
   PubMedGoogle Scholar
• Goromaru T., Matsuura H., Furuta T., Baba S., Yoshimura N., Miyazaki T., Sameshima T. Identification of fentanyl metabolites in rat urine by gas chromatography-mass spectrometry with stable-isotope tracers. Drug Metabolism and Disposition 1982; 10: 542–546
   PubMed Web of Science ®Google Scholar
• Goromaru T., Matsuura H., Furuta T., Baba S. Identification of isopropylantipyrine metabolites in rat and man by using stable isotope tracer techniques. Chemistry Pharmacology Bulletin 1984; 32: 3179–3186
   PubMedGoogle Scholar
• Hammar C. -G., Holmstedt B., Ryhage R. Mass fragmentography: Identification of chlorpromazine and its metabolites in human blood by a new method. Analytical Biochemistry 1968; 25: 532–548
   PubMed Web of Science ®Google Scholar
• Haskins N. J. The application of stable isotopes in biomedical research. Biomedical Mass Spectrometry 1982; 9: 269–277
   PubMedGoogle Scholar
• Horning M. G., Stillwell W. G., Griffin G. W., Tsang W. S. Epoxide intermediates in the metabolism of naphthalene by the rat. Drug Metabolism and Disposition 1980; 8: 404–414
   PubMed Web of Science ®Google Scholar
• Hucker H. B., Stauffer S. C., Balletto A. J., White S. D., Zacchei A. G., Arison B. H. Physiological disposition and metabolish of cyclobenzaprine in the rat, dog, rhesus monkey and man. Drug Metabolism and Disposition 1978; 6: 659–672
   PubMedGoogle Scholar
• Lehman J. P., Fenselau C. Synthesis of quaternary ammonium-linked glucuronides by rabbit hepatic microsomal UDP-glucuronyltransferase and analysis by fast-atom bombardment mass spectrometry. Drug Metabolism and Disposition 1982; 10: 446–449
   PubMed Web of Science ®Google Scholar
• Lehman J. P., Fenselau C., DePaulo J. R. Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine. Drug Metabolism Disposition 1983; 11: 221–225
   PubMed Web of Science ®Google Scholar
• McCloskey J. A., Stillwell R. N., Lawson A. M. Use of deuterium-labelled trimethylsilyl derivatives in mass spectrometry. Analytical Chemistry 1968; 40: 233–236
   Web of Science ®Google Scholar
• McMahon R. E., Sullivan H. R., Due S. L., Marshall S. J. The metabolite pattern of d-propoxyphene in man: The use of heavy isotopes in drug disposition studies. Life Science 1973; 12: 463–473
   Web of Science ®Google Scholar
• Miwa G. T., Walsh J. S., VandenHeuvel W. J. A., Arison B., Sestokas E., Buhs R., Rosegay A., Avermitilis S., Lu A. Y. H., Walsh M. A. R., Walker R. W., Taub R., Jacob T. A. The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes. Drug Metabolism and Disposition 1982; 10: 268–274
   PubMed Web of Science ®Google Scholar
• Miyazaki H., Abuki H. The use of stable isotopes in drug metabolism and pharmacokinetics. Advances in Pharmacology and Therapeutics II, Clinical Pharmacology, Teaching in Pharmacology, H. Yoshida, Y. Hagihara, E. Ebaski. Pergamon Press, Oxford and New York 1982; Vol. 6: 227–233
   Google Scholar
• Noda A., Goromaru T., Tsubone N., Matsuyama K., Iguchi S. In vivo formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine I. Chemistry Pharmacology Bulletin 1976; 24: 1502–1505
   PubMed Web of Science ®Google Scholar
• Porter C. C., Arison B. H., Gruber V. F., Titus D. C., Vanden Heuvel W. J. A. Human metabolism of cyproheptadine. Drug Metabolism and Disposition 1975; 3: 189–197
   PubMed Web of Science ®Google Scholar
• Prox A. Some applications of mass spectrometry in drug metabolism studies. Xenobiotica 1973; 3: 473–492
   PubMed Web of Science ®Google Scholar
• Rubin A., Dhahir P. H., Crabtree R. E., Henry D. P. The disposition of l — 3[(dimethylamino)-(m-dioxan-5-yl)methyl]pyridine in man. Drug Metabolism and Disposition 1979; 7: 149–154
   PubMed Web of Science ®Google Scholar
• Schmelz E., Schmidt H. L. Stable isotope-labelled molecules: indispensable tools in clinical diagnosis, pharmacology and nutritional sciences. Pharmacology International 1984; 5: 153–157
   Google Scholar
• Stillwell W. G., Horning M. G., Griffin G. W., Tsang W. S. Identification and synthesis of the isomeric tetrahydroxytetrahydronaphthalene metabolites excreted in rat urine. Drug Metabolism and Disposition 1932; 10: 11–14
   Google Scholar
• Stillwell W. G., Horning M. G., Griffin G. W., Tsang W. S. Identification of new sulfur-containing metabolites of naphthalene in mouse urine. Drug Metabolism and Disposition 1982; 10: 624–631
   PubMedGoogle Scholar
• Tocco D. J., Duncan A. E. W., DeLuna F. A., Smith J. L., Walker R. W., Vanden Heuvel W. J. A. Timolol metabolism in man and laboratory animals. Drug Metabolism and Disposition 1980; 8: 236–240
   PubMed Web of Science ®Google Scholar
• VandenHeuvel W. J. A., Carlin J. R., Ellsworth R. L., Wolf F. J., Walker R. W. Source of the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxy-carbonylaminobenzimidazole, a metabolite of cambendazole. Biomedical Mass Spectrometry 1974; 1: 190–191
   PubMedGoogle Scholar
• VandenHeuvel W. J. A. Drug metabolite identification: stable isotope methods. Journal of Clinical Pharmacology 1986; 26: 427–434
   PubMed Web of Science ®Google Scholar
• Vickers S., Stuart E. K., Bianchine J. R., Hucker H. B., Jaffe M. E., Rhodes R. E., Vanden Heuvel W. J. A. Metabolism of carbidopa[L-(-)-α-hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate], an aromatic amino acid decarboxylase inhibitor, in the rat, dog, rhesus monkey and man. Drug Metabolism and Disposition 1974; 2: 9–22
   PubMed Web of Science ®Google Scholar
• Vickers S., Stuart E. K., Hucker H. B., Vanden Heuvel W. J. A. Further studies on the metablism of carbidopa, (-)-L-α-hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid monohydrate, in the human, rhesus monkey, dog and rat. Journal of Medical Chemistry 1975; 18: 134–138
   PubMedGoogle Scholar
• Vore M., Sweetman B. J., Bush M. T. The metabolism of 1-n-butyl-5,5-diethyl-barbituric acid (N-n-butyl barbital) in the rat. The Journal of Pharmacology and Experimental Therapeutics 1974; 190: 384–394
   PubMed Web of Science ®Google Scholar