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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 4
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Original Article

The interaction between chronic oral slow-release theophylline and single-dose intravenous erythromycin

J. Pasic Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE, UK
,
S. H. D. Jackson Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE, UK
,
A. Johnston Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE, UK
,
C. A. Peverel-cooper Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE, UK
,
P. Turner Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE, UK
,
K. Downey Department of Pharmacology and Therapeutics, The London Hospital Medical College, Turner Street, London, E1 2AD, UK
&
D. M. Chaput De Saintonge Department of Pharmacology and Therapeutics, The London Hospital Medical College, Turner Street, London, E1 2AD, UK
 show all
Pages 493-497 | Received 07 May 1986, Published online: 30 Sep 2009

References

  • Chang J. C., Gotcher S., Gushaw J. B. Homogeneous enzyme immunoassay for theophylline in serum and plasma. Clinical Chemistry 1982; 28: 361–367
  • Efthimiou H., Morgan D. J., Ioannides-Demos L., Raymond K., Mclean A. J. Influence of chronic dosing on theophylline clearance. British Journal of Clinical Pharmacology 1984; 17: 525–530
  • Hildebrandt R., Moller H., Gundert-Remy U. Influence of theophylline administration on erythromycin kinetics. II World Conference on Clinical Pharmacology and Therapeutics. Washington, DC 1983, abstract no. 447
  • Hildebrandt R., Gundert-Remy U., Moller H., Weber E. Lack of clinically important interaction between erythromycin and theophylline. European Journal of Clinical Pharmacology 1984; 26: 285–489
  • Iliopoulou A., Aldhous M. E., Johnston A., Turner P. Pharmacokinetic interaction between theophylline and erythromycin. British Journal of Clinical Pharmacology 1982; 14: 495–499
  • Jackson S. H. D., Wiffen J. K., Smythe M. M., Johnston A. Is circadian variation in theophylline trough serum concentrations determined by time of dosing. British Journal of Clinical Pharmacology 1984; 17: 777–779
  • Johnston A., Woollard R. C. STRIPE: an interactive computer program for the analysis of drug pharmacokinetics. Journal of Pharmacological Methods 1983; 9: 193–200
  • La Force C. F., Miller M. F., Chai H. Effect of erythromycin on theophylline clearance in asthmatic children. Journal of Pediatrics 1981; 99: 153–156
  • Pfeifer H. J., Greenblatt D. J., Friedman P. Effects of three antibiotics on theophylline kinetics. Clinical Pharmacology and Therapeutics 1979; 26: 36–40
  • Reisz G., Pingleton S. K., Melethil S., Ryan P. B. The effect of erythromycin on theophylline pharmacokinetics in chronic bronchitis. American Review of Respiratory Disease 1983; 127: 581–584
  • Renton K. W., Gray J. D., Hung O. R. Depression of theophylline elimination by erythromycin. Clinical Pharmacology and Therapeutics 1981; 30: 422–426
  • Richer C., Mathieu M., Bah H., Thuillez C., Duroux P., Giudicelli J-F. Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: influence of erythromycin. Clinical Pharmacology and Therapeutics 1982; 31: 579–586
  • Tang-Liu D. D-S., Tozer T. N., Riegelman S. Urine flow dependence of theophylline renal clearance in man. Journal of Pharmacokinetics and Biopharmaceutics 1982; 10: 351–364

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