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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 5
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Research Article

The metabolism of 14C-DDT, 14C-DDD, 14C-DDE and 14C-DDMU in rats and Japanese quail

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Pages 525-538 | Received 18 Sep 1985, Published online: 22 Sep 2008

References

  • Abou-Donm M. B., Menzei D. B. The metabolism in viro of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the chick by embryonic injection and dietary ingestion. Biochemical Pharmacology 1968; 17: 2143–2160
  • Abou-Donia M. B., Menzel D. B. DDT: the degradation of ring-labeled 14C-DDT to 14CO2 in the rat. Experientia 1976; 32: 500–501
  • Ahmed M. M., Walker C. H. The metabolism of DDT in vivo by the Japanese quail (Coturnix coturnix Japonica). Pesticide Biochemistry and Physiology 1979; 10: 40–48
  • Apple E. J. Metabolism and Detoxification of DDT in Mammals. University of Arizona. 1968, Ph.D. Dissertation
  • Bailey S., Bunyan P. J., Rennison B. D., Taylor A. The metabolism of 1,1-di(p-chlorophenyl)-2,2,2-trichloroethane and 1,1-di(p-chlorophenyl)-2,2-dichloroethane in the pigeon. Toxicology and Applied Pharmacology 1969a; 14: 13–22
  • Bailey S., Bunyan P. J., Rennison B. D., Taylor A. The metabolism of 1,1-di(p- chlorophenyl)-2,2-dichlorothylene and 1,1-di(p-chlorophenyl)-2-chloroethylene in the pigeon. Toxicology and Applied Pharmacology 1969b; 14: 23–32
  • Bishara R. H., Born G. S., Christian J. E. Radiotracer distribution and excretion study of chlorophenothane in rats. Journal of Pharmaceutical Sciences 1972; 61: 1912–1916
  • Brown J. R., Hughes H., Viriyanondha J. Storage, distribution and metabolism of 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethanol. Toxicology and Applied Pharmacology 1969; 15: 30–37
  • Bunyan P. J., Page J. M. J. Pesticide-induced changes in hepatic microsomal enzyme systems. Some effects of 1,1-di(p-chlorophenyl)-2,2-dichloroethylene (DDE) and 1,1-di(p-chlorophenyl)-2-chloroethylene (DDMU) in the rat and Japanese quail. Chemico-biological Interactions 1973; 6: 249–257
  • Bunyan P. J., Townsend M. G., Taylor A. Pesticide-induced changes in hepatic microsomal enzyme systems. Some effects of DDT and DDE in the rat and Japanese quail. Chemico-biological Interactions 1972; 5: 13–26
  • Cooke A. S. Shell thinning in avian eggs by environmental pollutants. Environmental Pollution 1973; 4: 85–152
  • Datta P. R. In vivo detoxication of p, p'-DDT via p, p'-DDE to p, p'DDA in rats. Industrial Medicine 1970; 39: 49–53
  • Davison K. L., Sell J. L. Dieldrin and p, p'-DDT effects on some microsomal enzymes of livers of chickens and Mallard ducks. Journal of Agriculture and Food Chemistry 1972; 20: 1198–1205
  • Dilloway M. R., Bridges J. W., Bunyan P. J., Stanley P. I. Species differences in the effects of 1,1-di(4-chlorophenyl)-2-chloroethylene (DDMU) and 1,1-di(4-chlorophenyl)-2,2-dichloroethylene (DDE) on glutathione levels in isolated hepatocytes from Japanese quail and rat. Xenobiotica 1982; 12: 489–494
  • Fawcett S. C., Bunyan P. J., Huson L. W., King L. J., Stanley P. I. The excretion of radioactivity following the intraperitoneal administration of 14C-DDT, 14C-DDD, 14C-DDE and 14C-DDMU to the rat and Japanese quail. Bulletin of Environmental Contamination and Toxicology 1981a; 27: 386–392
  • Fawcett S. C., King L. J., Stanley P. I., Bunyan P. J. The synthesis of ring-U-14C-DDD from ring-U-14C-DDT. Journal of Labelled Compounds and Radiopharmaceuticals 1981b; 18: 1673–1675
  • Gatterdam P. E., De R. K., Guthrie F. E., Bowery T. G. The absorption, metabolism and excretion of C14-labeled TDE in certain insects. Journal of Economic Entomology 1964; 57: 258–264
  • Gillett J. W., Chan T. M., Terriere L. C. Interactions between DDT analogs and microsomal epoxidase systems. Journal of Agricultural and Food Chemistry 1966; 14: 540–545
  • Gingell R. Metabolism of 14C-DDT in the mouse and hamster. Xenobiotica 1976; 6: 15–20
  • Gold B., Brunk G. Metabolism of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane in the mouse. Chemico-biological Interactions 1982; 41: 327–339
  • Gold B., Brunk G. A mechanistic study of the metabolism of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) to 2,2-bis(p-chlorophenyl)-acetic acid (DDA). Biochemical Pharmacology 1984; 33: 979–982
  • Gold B., Leuschen T., Brunk G., Gingell R. Metabolism of a DDT metabolite via a choroepoxide. Chemico-biological Interactions 1981; 35: 159–176
  • Hart L. G., Fouts J. R. Further studies on the stimulation of hepatic microsomal drug metabolising enzymes by DDT and its analogs. Archiv für Experimentalle Pathologie und Pharmakologie 1965; 249: 486–500
  • Jensen J. A., Cueto C., Dale W. E., Rothe C. F., Pearce J. W., Mattson A. M. DDT metabolites in faeces and bile of rats. Journal of Agricultural and Food Chemistry 1957; 5: 919–925
  • Kovacs M. F. Rapid detection of chlorinated pesticide residues by an improved TLC (thin-layer chromatography) technique: 3.25x4 inch micro slides. Journal of the Association of Official Analytical Chemists 1966; 49: 365–370
  • Lamberton J. G., Inman R. D., Claeys R. R., Robson W. A., Arscott G. H. The metabolism of p, p'-DDE in laying Japanese quail and their incubated eggs. Bulletin of Environmental Contamination and Toxicology 1975; 14: 657–664
  • Mansuy D., Lange M., Chottard J. C. Reaction of 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) with iron (II) porphyrins. Isolation of the vinylidene carbene complex, tetraphenylporphyrin iron (II) (C = C(p-ClC6H4)2). Journal of the American Chemical Society 1978; 100: 3213–3214
  • Odam E. M., Townsend M. G. The determination of warfarin in animal tissues by electron-capture gas-liquid chromatography. Analyst 1976; 101: 478–484
  • Odam F. M., Tarrant K. A., Townsend M. G. Method for the elution of compounds from thin-layer chromatography plates. Laboratory Practice 1975; 24: 670
  • Peterson J. E., Robison W. H. Metabolic products of p, p'-DDT in the rat. Toxicology and Applied Pharmacology 1964; 6: 321–327
  • Sieber S. M. The lymphatic absorption of p, p'-DDT and some structurally related compounds in the rat. Pharmacology 1976; 14: 443–454
  • Sidra M. S., Walker C. H. The metabolism of p, p'-DDT by the feral pigeon (Columba livia). Pesticide Biochemistry and Physiology 1980; 14: 62–71
  • Sundstrom G. Metabolic hydroxylation of the aromatic rings of 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p, p'-DDE) by the rat. Journal of Agricultural and Food Chemistry 1977; 25: 18–21
  • Sundstrom G., Jansson B., Jensen S. Structure of phenolic metabolites of p, p'-DDE in the rat, wild seal and guillemot. Nature 1975; 255: 627–628
  • White W. C., Sweeney T. R. The metabolism of 2,2-bis-(p-chlorophenyl)-1,1,1-trichloroethane (DDT), 1. A metabolite from rabbit urine, di(p-chlorophenyl)-acetic acid; its isolation, identification and synthesis. Public Health Reports (U.S.) 1945; 60: 66–71
  • Williams P. L., Moefat A. C., King L. J. Combined high-performance liquid chromatography and radioimmunoassay method for the analysis of Δ9-THC metabolites in human urine. Journal of Chromatography 1979; 186: 595–603

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