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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 5
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Research Article

Temporal variations in paracetamol absorption and metabolism in man

F. Kamali Department of Therapeutics, University Hospital, Nottingham, UK
,
J. R. Fry Department of Therapeutics, University Hospital, Nottingham, UK; Department of Physiology and Pharmacology, Medical School, Queens Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK
&
G. D. Bell Department of Medicine, Ipswich Hospital, Heath Road Wing, Ipswich, Suffolk, UK
Pages 635-641 | Received 01 May 1986, Published online: 22 Sep 2008

References

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  • Glynn J. P., Bastain W. Salivary excretion of paracetamol in man. Journal ofPharmacy and Pharmacology 1973; 25: 420–421
  • Heading R. C., Nimmo J., Prescott L. F., Tothill P. The dependence of paracetamol absorption on the rate of gastric emptying. British Journal of Pharmacology 1973; 47: 415–421
  • Howie D., Adriaenssens P. I., Prescott L. F. Paracetamol metabolism following overdosage. Application of high performance liquid chromatography. Journal of Pharmacy and Pharmacology 1977; 29: 235–257
  • Jaffe J. M., Colaizzi, Barry H. Effects of dietary components on Gl absorption on acetaminophen tablets in man. Journal of Pharmaceutical Sciences 1971; 60: 1646–1650
  • Kamali F., Fry J. R., Smart H. L., Bell G. D. A double blind crossover study of the effect of sucralfate on paracetamol absorption. British Journal of Clinical Pharmacology 1985; 19: 113–114
  • Levy G., Yamada H. Drug biotransformation interactions in man. III. Acetaminophen and salicylamide. Journal of Pharmaceutical Sciences 1971; 60: 215–221
  • McGilveray I. J., Mattok G. L. Some factors affecting the absorption of paracetamol. Journal of Pharmacy and Pharmacology 1972; 24: 615–619
  • Miners J. O., Attwood J., Birkett D. J. Influence of sex and oral contraceptive steroids on paracetamol metabolism. British Journal of Clinical Pharmacology 1983; 16: 503–509
  • Moore J. G., Christian P. E., Colman R. E. Gastric emptying of varying meal weight and composition in man. Digestive Diseases and Sciences 1981; 26: 16–22
  • Nimmo W. S., Prescott L. F. The influence of posture on paracetamol absorption. British Journal of Clinical Pharmacology 1978; 2: 509–513
  • Schnell R. C., Bozigian H. P., Davies M. H., Merrick B. A., Johnson K. L. Circadian rhythm in acetaminophen toxicity; role of non-protein sulfhydryls. Toxicology and Applied Pharmacology 1983; 71: 353–361
  • Shively C. A., Vesell E. S. Temporal variations in acetaminophen and phenacetin half-life in man. Clinical Pharmacology and Therapeutics 1975; 18: 413–424

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