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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 6
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Original Article

Influence of substrate concentration on the phase I and phase II metabolism of 4-methoxybiphenyl by rat isolated hepatocytes

Pages 751-758 | Received 02 Jun 1986, Published online: 30 Sep 2009

References

  • Campbell R. C. Statistics for Biologists. Cambridge University Press, London 1967; 49–50
  • Eyer P., Kampffmeyer H. G. Biotransformation of 4-dimethylaminophenol in the isolated perfused rat liver and in the rat. Biochemical Pharmacology 1978; 27: 2223–2228
  • Fry J. R. A comparison of biphenyl 4-hydroxylation and 4-methoxybiphenyl O-demethylation in rat liver microcomes. Biochemical Pharmacology 1981a; 30: 1915–1919
  • Fry J. R. Preparation of mammalian hepatocytes. Methods in Enzymology, W. B. Jakoby. Academic Press, New York 1981b; Vol 77: 130–137
  • Koike M., Sugeno K., Hirata M. Sulfoconjugation and glucuronidation of salicylamide in isolated rat hepatocytes. Journal of Pharmaceutical Sciences 1981; 70: 308–311
  • Koster H., Mulder G. J. Apparent aberrancy in the kinetics of intracellular metabolism of a single substrate by two enzymes. Drug Metabolism and Disposition 1982; 10: 330–335
  • Koster H., Halsema I., Scholtens E., Knippers M., Mulder G. J. Dose-dependent shifts in the sulfation and glucuronidation of phenolic compounds in the rat in vivo and in isolated hepatocytes. Biochemical Pharmacology 1981; 30: 2569–2575
  • Koster H., Halsema I., Scholtens E., Pang K. S., Mulder G. J. Kinetics of sulfation and glucuronidation of harmol in the perfused rat liver preparation. Biochemical Pharmacology 1982; 31: 3023–3028
  • Levy G., Matsuzawa T. Pharmacokinetics of salicylamide elimination in man. Journal of Pharmacology and Experimental Therapeutics 1967; 156: 285–293
  • Minck K., Schupp R. R., Illing M. P. A., Kahl G. F., Netter K. J. Interrelationship between demethylation of p-nitroanisole and conjugation of p-nitrophenol in rat liver. Naunyn-Schmiedeberg's Archives of Pharmacology 1973; 279: 347–360
  • Moldeus P., Vadi H., Berggren M. Oxidative and conjugative metabolism of p-nitroanisole and p-nitrophenol in isolated rat liver cells. Acta Pharmacologia et Toxicologia 1976; 39: 19–32
  • Mulder G. J., Dawson J. R., Pang K. S. Competition between sulphation and glucuronidation in the rat in viro: enzyme kinetics and pharmacokinetics of conjugation. Biochemical Society Transactions 1984; 12: 17–20
  • Paterson P., Fry J. R. Influence of cytochrome P-450 type on the pattern of conjugation of 4-hydroxybiphenyl generated from biphenyl or 4-methoxybiphenyl. Xenobiotica 1985; 15: 493–502
  • Sundheimer D. W., Brendel K. Metabolism of harmol and transport of harmol conjugates in isolated rat hepatocytes. Drug Metabolism and Disposition 1983; 11: 433–440
  • Wiebkin P., Fry J. R., Jones C. A., Lowing R. K., Bridges J. W. Biphenyl metabolism in isolated rat hepatocytes: effect of induction and nature of the conjugates. Biochemical Pharmacology 1978; 27: 1899–1907

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