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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 6
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Original Article

The detection of cytotoxicity produced by short-lived reactive intermediates: a study with bromobenzene

S. A. Horner Department of Human Morphology, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG, 7 2UH, UK
,
J. R. Fry Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG, 7 2UH, UK
,
R. H. Clothier Department of Human Morphology, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG, 7 2UH, UK
&
M. Balls Department of Human Morphology, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG, 7 2UH, UK
Pages 777-782 | Received 15 Apr 1986, Accepted 21 Jul 1986, Published online: 30 Sep 2009

References

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  • Pessayre D., Dolder A., Artigou J. -Y., Wandscheer J. -C., Descatoire V., Degott C., Behhamou J. -P. Effect of fasting on metabolite-mediated hepatotoxicity in the rat. Gastroenterology 1979; 77: 264–271
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  • Thor H., Moldeus P., Hermanson R., Hogberg J., Reed D. J., Orrenius S. Metabolic activation and hepatotoxicity: toxicity of bromobenzene in hepatocytes isolated from phenobarbital- and diethylmaleate-treated rats. Archives of Biochemistry and Biophysics 1978; 188: 122–129
  • Weaver F. A., Torkelson A. R., Zybmunt W. A., Browder H. P. Tissue culture cytotoxicity assay for cyclophosphamide metabolites in rat body fluids. Journal of Pharmaceutical Science 1978; 67: 1009–1012
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