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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 7
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Original Article

The effects of general anaesthesia on tocainide clearance in the sheep

W. B. Runciman Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Adelaide, South Australia, 5042, Australia
,
L. E. Mather Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Adelaide, South Australia, 5042, Australia
,
R. J. Carapetis Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Adelaide, South Australia, 5042, Australia
,
A. H. Ilsley Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Adelaide, South Australia, 5042, Australia
&
C. F. Mclean Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Adelaide, South Australia, 5042, Australia
Pages 807-813 | Received 20 Mar 1986, Published online: 30 Sep 2009

References

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  • Bennett P. N., Notarianni L. J., Supradist S. Alteration of liver blood flow and metabolism on lignocaine and tocainide kinetics; observed changes and predictions of pharmaco-kinetic models. British Journal of Pharmacology 1981; 73: 273P–274P
  • Elvin A. T., Keenaghan J. B., Byrnes E. W., Tenthorney P. A., McMaster P. D., Takman B. H., Lalka D., Meyer M. B., Ronfeld R. A. Tocainide conjugation in humans. Journal of Pharmaceutical Sciences 1980; 69: 47–49
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  • Gipple K. J., Chan K. T., Elvin A. T., Lalka D., Axelson J. E. Species differences in the urinary excretion of the novel primary conjugate: tocainide carbamoyl-O-beta-D glucuronide. Journal of Pharmaceutical Sciences 1982; 71: 1011–1014
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  • Mather L. E., Ringrose R. L., Austin K. L. Determination of pharmacokinetic constants preparation for studying interactions between blood flow and drug disposition. V: The effects of general and subarachnoid anaesthesia on blood flow and pethidine disposition. British Journal of Anaesthesia 1982; 58: 888–896
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  • Ronfeld R. A. Pharmacokinetics of new antiarrhythmic drugs. Cardiac Arrhythmias: A Decade of Progress, D. C. Harrison. G. K. Hall, Boston 1981; 135–145
  • Runciman W. B., Mather L. E. Effects of anaesthesia on drug disposition. Mechanism of Action of Drugs in Anaesthetic Practice, S. A. Feldman, C. F. Scurr, W. Paton. Edward Arnold, London 1986; 87–122
  • Runciman W. B., Ilsley A. H., Mather L. E., Carapetis R., Rao M. A sheep preparation for studying interactions between blood flow and drug disposition. I: Physiological profile. British Journal of Anaesthesia 1984a; 56: 1015–1028
  • Runciman W. B., Mather L. E., Ilsley A. H., Carapetis R., Mclean C. F. A sheep preparation for studying interactions between blood flow and drug disposition. II: Experimental applications. British Journal of Anaesthesia 1984b; 56: 1117–1129
  • Runciman W. B., Mather L. E., Ilsley A. H., Carapetis R., Upton R. N. A sheep preparation for studying interactions between blood flow and drug disposition. III: Effects of general and spinal anaesthesia on regional blood flow and oxygen tensions. British Journal of Anaesthesia 1984c; 56: 1247–1258
  • Runciman W. B., Mather L. E., Ilsley A. H., Carapetis R. J., Upton R. N. A sheep preparation for studying interactions between blood flow and drug disposition. IV The effects of general and spinal anaesthesia on blood flow and cefoxitin disposition. British Journal of Anaesthesia 1985; 57: 1239–1247
  • Runciman W. B., Mather L. E., Ilsley A. H., Carapetis R., Upton R. N. A sheep preparation for studying interactions between blood flow and drug disposition. IV: Effects of general or subarachnoid anaesthesia on blood flow and chlormethiazole disposition. British Journal of Anaesthesia 1986; 58: 1308–1316
  • Tucker G. T., Wiklund L., Berlin-Wahlen A., Mather L. E. Hepatic clearance of local anaesthetics in man. Journal of Pharmacokinetics and Biopharmaceutics 1977; 5: 111–122

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