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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 7
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Original Article

Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations

Thomas F. Woolf Departments of Pharmacology and Pharmaceutical Chemistry, University of California, San Francisco, CA, 94143, USA; Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Pharmaceutical Research, 2300 Plymouth Rd, Ann Arbor, MI, 48105, USA
&
James D. Adams Departments of Pharmacology and Pharmaceutical Chemistry, University of California, San Francisco, CA, 94143, USA; School of Pharmacy, Washington State University, Pullman, WA, 99164–6510, USA
Pages 839-847 | Received 18 Jun 1986, Published online: 30 Sep 2009

References

  • Adams J. D., Baillie T. A., Trevor A. J., Castagnoli N. Studies on the biotransformation of ketamine. 1. Identification of metabolites produced in vitro from rat liver microsomal preparations. Biomedical Mass Spectrometry 1981; 8: 527–538
  • Chang T., Glasko A. J. Biotransformation and disposition of ketamine. International Anesthesiology Clinics 1974; 12: 157–177
  • Chang T., Dill W. A., Glasko A. J. Metabolic disposition of 2-(o-chlorophenyl)-2-methylaminocyclohexanone · HCl (Cl-581) in laboratory animals and in man. Federation Proceedings 1965; 24: 268
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  • Little B., Chang T., Chucot K., Dill W. A., Eurile L. L., Glasko A. J., Jassain M., Kretchner H., Sweet A. Y. Study of ketamine as an obstetric anesthetic agent. American Journal of Obstetrics and Gynecology 1972; 113: 247–260
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  • Marrietta M. A., Way W. A., Castagnoli N., Trevor A. J. On the pharmacology of the ketamine enantiomorphs in the rat. Journal of Pharmacology and Experimental Therapeutics 1977; 202: 157–165
  • Nash T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochemical Journal 1953; 55: 416–421
  • Ryder S., Way W. L., Trevor A. J. Comparative pharmacology of the optical isomers of ketamine in mice. European Journal of Pharmacology 1978; 49: 15–23
  • Woolf T., Trevor A., Baillie T., Castagnoli N. Synthesis of (Z) and (E)-6-Hydroxyketamine. Journal of Organic Chemistry 1984; 49: 3305–3310

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