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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 7
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Original Article

Metabolism of procyclidine in isolated rat hepatocytes

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Pages 849-857 | Received 18 Jun 1986, Published online: 30 Sep 2009

References

  • Berry M. N., Friend D. S. High yield preparation of isolated rat liver parenchymal cells. Journal of Cell Biology 1969; 43: 506–520
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randal R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Mindham R. H. S., Lamb P., Bradley R. A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism. British Journal of Psychiatry 1977; 130: 581–585
  • Moldeus P. Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochemical Pharmacology 1978; 27: 2859–2863
  • Paeme G., Grimee R., Vercruysse A. Carbon-13 chemical shifts of three oxo-, six monohydroxy-, and six dihydroxycyclohexyl derivatives of procyclidine. Bulletin de Societes Chimiques Belges 1982; 91: 641–651
  • Paeme G., Grimee R., Vercruysse A. In vitro metabolism of procyclidine in the rat. European Journal of Drug Metabolism and Pharmacokinetics 1984a; 9: 311–313
  • Paeme G., Grimee R., Vercruysse A. Isolation and identification of eight procyclidine metabolites from rat urine. European Journal of Drug Metabolism and Pharmacokinetics 1984b; 9: 103–108
  • Rogiers V., Vandenberghe V., Vercruysse A. Inhibition of gluconeogenesis by sodium valproate and its metabolites in isolated rat hepatocytes. Xenobiotica 1985; 15: 759–765
  • Schoene B., Fleischmann R. A., Remmer H. Determination of drug metabolizing enzymes in needle biopsies of human livers. European Journal of Clinical Pharmacology 1972; 4: 65–73
  • Seglen P. O. Methods in Cell Biology. Academic Press, New York 1976; 30–83

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