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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 12
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Original Article

Metabolism of the anti-obesity agent, 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride, in rats and dogs

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Pages 1405-1414 | Received 13 Oct 1986, Published online: 30 Sep 2009

References

  • Altman P. L. Biological Handbooks. “Blood and Other Body Fluids”, D. S. Dittmer. Federation of American Societies for Experimental Biology, Washington, DC 1961; 1–5
  • Ansher S. S., Jakgby W. B. Amine N-methyltransferases from rabbit liver. Journal of Biological Chemistry 1986; 261: 3996–4001
  • Axelrod J. The enzymatic N-methylation of serotonin and other amines. Journal of Pharmacology and Experimental Therapeutics 1963; 138: 28–38
  • Axelrod J. Methylation reactions in the formation and metabolism of catecholamines and other biogenic amines. Pharmacological Reviews 1966; 18: 95–113
  • Brooks M. A., Lee T. L. Determination of 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester and its acid metabolite in plasma and urine by high-performance liquid chromatography. Journal of Chromatography 1985; 345: 333–343
  • Confalone P. N., Pizzolato G., Uskokovic M. R., Rouge M. Novel Thiophene Derivatives. United States Patent No. 4,317,915, 2 March, 1982
  • Fong K. -L. L., Hwang B. Y. H. Dog liver N-methyltransferase, a new drug-metabolizing enzyme. Biochemical Pharmacology 1983; 32: 2781–2786
  • Garteiz D. A. Metabolism of a beta blocking drug, oxprenolol. Journal of Pharmacology and Experimental Therapeutics 1971; 179: 354–358
  • Harman R. E., Meisinger M. A. P., Davis G. E., Kuehl F. A., Jr. The metabolites of indomethacin, a new anti-inflammatory drug. Journal of Pharmacology and Experimental Therapeutics 1964; 143: 200–215
  • Inoue M., Morikawa M., Tsuboi M., Yamada T., Sugiura M. Hydrolysis of ester-type drugs by the purified esterase from human intestinal mucosa. Japanese Journal of Pharmacology 1979; 29: 17–25
  • Iwamoto K., Klaassen C. D. First-pass effect of morphine in rats. Journal of Pharmacology and Experimental Therapeutics 1977; 200: 236–244
  • Leeson G. A., Garteiz D. A., Knapp W. C., Wright G. J. N-methylation, a newly identified pathway in the dog for the metabolism of oxprenolol, a β-receptor blocking agent. Drug Metabolism and Disposition 1973; 1: 565–568
  • Lund B., Kampmann J. P., Lindahl F., Hansen J. M. Pivampicillin and ampicillin in bile, portal and peripheral blood. Clinical Pharmacology and Therapeutics 1976; 19: 587–591
  • Mansuy D., Dansette P. M., Foures C., Jaouen G., Moinet G., Bayer N. Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rats. Biochemical Pharmacology 1984; 33: 1429–1435
  • Rowland M., Riegelmann S., Harris P. A., Sholkoff S. D., Eyring E. J. Kinetics of acetylsalicylic acid disposition in man. Nature 1967; 215: 413–414
  • Spenney J. G., Nowell R. M. Acetylsalicylate hydrolase of rabbit gastric mucosa. Isolation and purification. Drug Metabolism and Disposition 1979; 7: 215–219
  • Szuna A. J., Loh A. C., Sasso G. J., Williams T. H., Triscari J., Leinweber F. -J. Tissue distribution and metabolism of Ro 22–0654, a novel lipid synthesis inhibitor, in rats. Pharmacologist 1983; 25: 173
  • Szuna A. J., Loh A. C., Carbone J. J., Williams T. H., Sasso G. J., Baggiolini E., Leinweber F. -J. The metabolism of Ro 22–0654, a novel fatty acid synthesis inhibitor, in dogs. Pharmacologist 1985; 27: 122
  • Triscari J., Sullivan A. C. Antiobesity effects of a novel lipid synthesis inhibitor (Ro 22–0654). Life Sciences 1984a; 34: 2433–2442
  • Triscari J., Sullivan A. C. Anti-obesity activity of a novel lipid synthesis inhibitor. International Journal of Obesity 1984b; 8(Suppl. 1)227–239
  • Triscari J., Greenwood M. R. C., Sullivan A. C. Regulation of lipid synthesis in hepatocytes from lean and obese Zucker rats. Metabolism 1981; 30: 1135–1142
  • Walle U. K., Wilson M. J., Walle T. Propanolol, alprenolol and oxprenolol metabolism in the dog. Identification of N-methylated metabolites. Biomedical Mass Spectrometry 1981; 8: 78–84

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