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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 8
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Original Article

Studies on the metabolism of aristolochic acids I and II

G. Krumbiegel Dr Madaus GmbH & Co., Department of Biochemistry, Ostmerheimer Str. 198, D-5000 Cologne 91FR, Germany
,
J. Hallensleben Dr Madaus GmbH & Co., Department of Biochemistry, Ostmerheimer Str. 198, D-5000 Cologne 91FR, Germany
,
W. H. Mennicke Dr Madaus GmbH & Co., Department of Biochemistry, Ostmerheimer Str. 198, D-5000 Cologne 91FR, Germany
,
N. Rittmann Dr Madaus GmbH & Co., Department of Biochemistry, Ostmerheimer Str. 198, D-5000 Cologne 91FR, Germany
&
H. J. Roth Pharmaceutical Institute, University of Tübingen, Auf der Morgenstelle 8, D-7400 Tübingen 1, FR, Germany
Pages 981-991 | Received 28 Oct 1986, Published online: 30 Sep 2009

References

  • Batsford S., Kluthe R., Vogt A. Stimulation of phagocytosis by aristolochic acid in healthy subjects. Planta medica 1980; 39: 234–235
  • Hahn G. Die Osterluzei—Aristolochia clematitis—eine alte Medizinalpflanze. Dr. Med 1979; 1979(8)41–43
  • Hideg K., Hankovszky O. H., Méhes J. Estimation of aristolochic acid and some of its derivatives by paper chromatography and spectrophotometry in body fluids. Acta Physiologica Academiae Scientiarum Hungaricae 1963; 23: 79–84
  • Kluthe R., Vogt A., Batsford S. Doppelblindstudie zur Beeinflussung der Phagozytosefähigkeit von Granulozyten durch Aristolochiasäure. Arzneimittel-Forschung (Drug Research) 1982; 32(1)443–445
  • Krumbiegel G., Roth H. J. Partialsynthetische Aristolochiasäure-I-und -II-derivate als Vergleichsmaterial zu Stoffwechselprodukten der Ratte. Archiv der Pharmazie 1987; 320: 264–270
  • Kupchan S. M., Merianos J. J. The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indica. The Journal of Organic Chemistry 1968; 33: 3735–3738
  • Maguire J. H., Butler T. C., Dudley K. H. 5-Ethyl-5-phenylhydanton N-glucuronide, the major urinary metabolite of 5-ethyl-5-phenylhydantoin (nirvanol) in the dog. Drug Metabolism and Disposition 1982; 10: 595–598
  • Mengs U., Lang W., Poch J. -A. The carcinogenic action of aristolochic acid in rats. Archives of Toxicology 1982; 51: 107–119
  • Mengs U. On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Archives of Toxicology 1983; 52: 209–220
  • Mix D. B., Guinaudeau H., Shamma M. The aristolochic acids and aristolactams. Journal of Natural Products (Lloydia) 1982; 45: 657–666
  • Priestap H. A. Seven aristololactams from. Aristolochia argentina, Photochemistry 1985; 24: 849–852
  • Schmeiser H. H., Pool B. L., Wiessler M. Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver. Carcinogenesis 1986; 7: 59–63
  • Schulz M., Weist F., Gemählich M. Dünnschichtchromatographischer Nachweis der Aristolochia-Säure in verschiedenen Körperflüssigkeiten. Arzneimittel-Forschung (Drug Research) 1971; 21: 934–936

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