Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 9
Submit an article Journal homepage
16
Views
15
CrossRef citations to date
0
Altmetric
Research Article

Deposition of viprostol (a synthetic PGE2 vasodilator) in the skin following topical administration to laboratory animals

G. Nicolau Department of Pharmacodynamics, Medical Research Division, Pearl River, New York 10965, USA
,
R. A. Baughman Department of Pharmacodynamics, Medical Research Division, Pearl River, New York 10965, USA
,
A. Tonelli Department of Pharmacodynamics, Medical Research Division, Pearl River, New York 10965, USA
,
W. McWilliams Department of Pharmacodynamics, Medical Research Division, Pearl River, New York 10965, USA
,
J. Schiltz Shulton Skincare Research Center, American Cyanamid Company, Pearl River, New York 10965, USA
&
A. Yacobi Department of Pharmacodynamics, Medical Research Division, Pearl River, New York 10965, USA
Pages 1113-1120 | Received 13 Oct 1986, Published online: 22 Sep 2008

References

  • Ando H. Y., Ho N. F. N., Higuchi W. I. Skin as an active metabolizing barrier 1: Theoretical analysis of topical bioavailability. Journal of Pharmaceutical Sciences 1977; 66(11)1525
  • Birnbaum J. E., Chan P. S., Cervoni P., Dessy F., Van Humbeeck L. Cutaneous erythema and blood pressure lowering effects of topically applied 16-vinyl prostaglandins. Prostaglandins 1982a; 23(2)185
  • Birnbaum J. E., Cervoni P., Chan P. S., Chen S. M., Floyd M. B., Grudzinskas C. V., Weiss M. J., Dessy F. Prostaglandins and cogeners. (16S)-(pT)-15-deoxy-16-hydroxy-16-vinyl prostaglandin E2, an orally and transdermally active hypotensive agent of prolonged duration. Journal of Medicinal Chemistry 1982b; 25: 492
  • Guy R. H., Hadgraft J. Skin Metabolism: Theoretical. Percutaneous Absorption, R. L. Bronaugh, H. I. Maibach. Marcel Dekker Inc. Publisher, New York 1985; 57
  • Kao J., Patterson F. K., Hall J. Skin penetration and metabolism of topically applied chemicals in six mammalian species, including man: An in vitro study with benz(a)pyrene and testosterone. Toxicology and Applied Pharmacology 1985; 81: 502
  • Nicoľau G., Batra V. K., Gordon S., Tonelli A., McWilliams W. Transdermal absorption of DHV-PGE2 prostaglandin in the rat. Vth International Conference on Prostaglandins. 1982; 506, Abstracts
  • Nicolau G., Dahlin D., Kohlbrenner M., Chan P. S., Ronsberg M. A., Saunders T. K., Yacobi A., Cervoni P. Skin metabolism and transdermal absorption of viprostol, a synthetic PGE2, in the rat; effect of vehicle. Drug Metabolism and Disposition. 1986a, (submitted)
  • Nicolau G., Cosulich D. B., Tonelli A., Chen S. M., Pruzinsky M. S., Blum D. Metabolism of viprostol–A synthetic vasodilator PGE2 analog. Prostaglandins 1986b; 31: 811
  • Scheuplein R. J., Bronaugh R. L. Percutaneous absorption. Biochemistry and Physiology of the Skin, L. A. Goldsmith. Oxford Univ. Press, New York 1983; Vol. 2: 1255–1295
  • Yacobi A., Baughman R. A., Cosulich D. B., Nicolau G. Method for determination of first-pass metabolism in human skin. Journal of Pharmaceutical Sciences 1985; 73(10)1499

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.