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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 1
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Original Article

Disposition of new sulphur-containing 2-(chloroethyl)nitrosoureas in rats

D. Godenèche Institut National de la Santé et de la Recherche Médicale, Unit 71, BP 184, 63005 Clermont-Ferrand, and Facultié de Médecine,Services de Biophysique et de Cancérologie, 28, Place Henri Dunant, 63001 Clermont-Ferrand, France
,
J. C. Madelmont Institut National de la Santé et de la Recherche Médicale, Unit 71, BP 184, 63005 Clermont-Ferrand, and Facultié de Médecine,Services de Biophysique et de Cancérologie, 28, Place Henri Dunant, 63001 Clermont-Ferrand, France
,
P. Labarre Institut National de la Santé et de la Recherche Médicale, Unit 71, BP 184, 63005 Clermont-Ferrand, and Facultié de Médecine,Services de Biophysique et de Cancérologie, 28, Place Henri Dunant, 63001 Clermont-Ferrand, France
,
R. Plagne Institut National de la Santé et de la Recherche Médicale, Unit 71, BP 184, 63005 Clermont-Ferrand, and Facultié de Médecine,Services de Biophysique et de Cancérologie, 28, Place Henri Dunant, 63001 Clermont-Ferrand, France
&
G. Meyniel Institut National de la Santé et de la Recherche Médicale, Unit 71, BP 184, 63005 Clermont-Ferrand, and Facultié de Médecine,Services de Biophysique et de Cancérologie, 28, Place Henri Dunant, 63001 Clermont-Ferrand, France
Pages 59-70 | Received 15 Dec 1985, Published online: 30 Sep 2009

References

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  • MADELMONT, J. C., MOREAU, M. F., GODENÈCHE, D., DUPRAT, J., PLAGNE, R., and MEYNIEL, G., 1982, Main metabolites of 1-(2-chloroethyl)-341'-(5'-p-nitrobenzoy1-2',3'-isopropylidene)-D-ribofuranosyl]-1-nitrosourea and 1 -(2-chloroethyl)-3-(2',3',4'-tri-0-acetyl-n-ribopyranosyl)-1-nitrosourea in rats. Drug Metabolism and Disposition, 10, 662–666.
  • MADELMONT, J. C., GoneNicHE, D., PARRY, D., DUPRAT, J., CHABARD, J. L., PLAGNE, R., MATHE, G., and MEYNIEL, G., 1985 a, New cysteamine 2-chloroethyl nitrosoureas. Synthesis and preliminary antitumor results. Journal of Medicinal Chemistry, 28, 1346–1350.
  • MADELMONT, J. C., PARRY, D., GODENÈCHE, D., and DUPRAT, J., 1985 b, Utilisation de l'éthanolamine 'C comme précurseur: marquage de la N'-(chloro-2 ethyl) N-[(methylsulphiny1)-2 ethyl] N'-nitrosouree et de la N'-(chloro-2 ethyl) N-[(methylsulphonyI)-2 ethyl] N'-nitrosourie par "C. Journal of Labelled Compounds and Radiopharmaceuticals, XXII, 851–862.
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  • REED, D. J., and MAY, H. E., 1975, Alkylation and carbamoylation intermediates of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl- 1 -nitrosourea (CCNU). Life Science, 16, 1263–1270.

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