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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 10
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Original Article

Metabolism and pharmacokinetics of cinobufagin

S. Tõma Research Laboratory, Kyushin Pharmaceutical Co., Ltd, 1-31-7 Wada, Suginami-ku, Tokyo, 166, Japan
,
S. Morishita Research Laboratory, Kyushin Pharmaceutical Co., Ltd, 1-31-7 Wada, Suginami-ku, Tokyo, 166, Japan
,
K. Kuronuma Research Laboratory, Kyushin Pharmaceutical Co., Ltd, 1-31-7 Wada, Suginami-ku, Tokyo, 166, Japan
,
Y. Mishima Research Laboratory, Kyushin Pharmaceutical Co., Ltd, 1-31-7 Wada, Suginami-ku, Tokyo, 166, Japan
,
Y. Hirai Research Laboratory, Kyushin Pharmaceutical Co., Ltd, 1-31-7 Wada, Suginami-ku, Tokyo, 166, Japan
&
M. Kawakami Research Laboratory, Kyushin Pharmaceutical Co., Ltd, 1-31-7 Wada, Suginami-ku, Tokyo, 166, Japan
Pages 1195-1202 | Received 29 Sep 1986, Published online: 30 Sep 2009

References

  • Akera T., Brody T. M. The role of Na+ K+ -ATPase in the inotropic action of digitalis. Pharmacological Reviews 1977; 29: 187–220
  • Aoki K., Aoki M., Hirai Y., Kuroiwa Y. Enzyme immunoassay for cinobufagin. Chemical Pharmaceutical Bulletin 1986; 34: 1184–1188
  • Björkhem I., Danielsson H. Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by D̃4-3-oxosteroid 5β-reductase and 3α-hydroxysteroid dehydrogenase from rat liver. European Journal of Biochemistry 1970; 12: 80–84
  • Chen K. K., Kovarikova A. Pharmacology and toxicology of Toad venom. Journal of Pharmaceutical Sciences 1967; 56: 1535–1541
  • Chen K. K., Anderson R. C., Henderson F. G. Comparison of cardiac action of bufalin, cinobufotalin, and telocinobufagin with cinobufagin. Proceedings of the Society of Experimental Biology Medicine 1951; 76: 372–374
  • Heyns W., Moor P. D. A 3(17)β-hydroxysteroid dehydrogenase in rat erythrocytes. Biochimica et Biophysica Acta 1974; 358: 1–13
  • Kamano Y. The chemistry of toad poisons; recent advances in toad bufadienolides. Kagaku No Ryoiki 1970; 24: 339–354
  • Kim D., Akera T., Brody T. M. Inotropic actions of doxorubicin in isolated guinea-pig atria: evidence for lack of involvement of Na+ K+ -adenosine triphosphatase. Journal of Pharmacology and Experimental Therapeutics 1980; 214: 368–374
  • Komatsu M., Okano T. Separation of bufo-steroids by eluting dry column chromatography on silica gel. Yakugaku Zasshi 1967; 87: 712–718
  • Morishita S., Saito T., Mishima Y., Mizutani A., Hirai Y., Kawakami M. Pharmacological studies of cinobufagin, in comparison with digitoxin. Nippon Yakurigaku Zasshi 1985; 86: 269–292
  • Okada M., Suga T. Pharmacology of the principles isolated from Senso (Ch'an Su), the dried venom of the Chinese toad. Asian Medical Journal 1962; 5: 353–361
  • Pettit G. R., Kamano Y. Bufadienolides. 21. Synthesis of cinobufagin from bufotalin. Journal of Organic Chemistry 1972; 37: 4040–4044
  • Shimada K., Ishii N., Ohishi K., Ro J. S., Nambara T. Structure-activity relationship of cardiac steroids having a doubly linked sugar and related compounds for the inhibition of NA+ K+ - adenosine triphosphatase. Journal of Pharmacobio-Dynamics 1986; 9: 755–759
  • Stohs S. T., Reinke L. A., El–Olemy M. M. Metabolism in vitro of digitoxigenin by rat liver homogenates. Biochemical Pharmacology 1971; 20: 437–446
  • Suga T. The chemistry and pharmacology of senso (Ch'an Su). Taisha 1973; 10: 762–774
  • Yoshida S., Kamano Y., Sakai T. Studies of the surface anesthetic activity of bufadienolides isolated from Ch'an Su. Chemical Pharmaceutical Bulletin 1976; 24: 1714–1717

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