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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 10
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Original Article

Pharmacokinetics and metabolism of α-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol, a hypoglycemic agent, in man

F. L. S. Tse Department of Drug Metabolism, Sandoz Research Institute, East Hanover, New Jersey, 07936, USA
,
B. A. Orwig Department of Drug Metabolism, Sandoz Research Institute, East Hanover, New Jersey, 07936, USA
,
J. M. Jaffe Department of Drug Metabolism, Sandoz Research Institute, East Hanover, New Jersey, 07936, USA
&
J. G. Dain Department of Drug Metabolism, Sandoz Research Institute, East Hanover, New Jersey, 07936, USA
Pages 1259-1267 | Received 28 Oct 1986, Published online: 30 Sep 2009

References

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  • Doddrell D. M. D. T., Bendall M. R. Distortionless enhancement of NMR signals by polarization transfer. Journal of Magnetic Resonance 1982; 48: 323–327
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  • Toothaker R. D., Welling P. G. Effect of dose size on the pharmacokinetics of intravenous hydrocortisone during endogenous hydrocortisone suppression. Journal of Pharmacokinetics and Biopharmaceutics 1982; 10: 147–156
  • Tse F. L. S., Orwig B. A., Chang T., Guarducci L., Jaffe J. M. Effect of age on the disposition of α-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)-1H-3-indole-methanol in the rat. Drugs under Experimental and Clinical Research 1984; 10: 225–234
  • Tse F. L. S., Orwig B., Jaffe J. M. Disposition of α-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol (59–801), a hypoglycemic agent, in rats, dogs and monkeys. Xenobiotica 1987; 17: 741–749

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