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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 2
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Original Article

The metabolism of 35S-D-penicillamine in man

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Pages 235-244 | Received 13 Feb 1987, Published online: 30 Sep 2009

References

  • Abraham E. P., Chain E., Baker W., Robinson R. Penicillamine, a characteristic degradation product of penicillin. Nature 1943; 151: 107
  • Abraham E. P., Baker W., Chain E., Florey H. W., Holiday E. R., Robinson R. Nitrogenous character of penicillin. Nature 1942; 149: 356
  • Alicino J. F. Discovery of sulfur in penicillin. Archives of Biochemistry 1950; 27: 221–222
  • Aposhian H. V. Protection by D-penicillamine against the lethal effects of mercuric chloride. Science 1958; 128: 93
  • Aposhian H. V., Bradham L. S. Metabolism in vitro of the disulphhydryl amino acids, L-and D-penicillamine. Biochemical Pharmacology 1959; 3: 38–41
  • Aposhian H. V., Blair R. M., Morris M., Smithson C. H. The reversal of the inhibitory activity of L-penicillamine by branched chain amino acids. Biochimica et Biophysica Acta 1959; 36: 93–101
  • Barnsley E. A., Eskin N. A. M., James S. P., Waring R. H. The acetylation of S-alkylcysteines by the rat. Biochemical Pharmacology 1968; 18: 2393–2401
  • Berg C. J., Kaczka E. A., Folkers K. British patent. 621, 915., 1949, Penicillamine disulphides. Apr. 22nd. (Merck & Co., Inc.)
  • Bergstrom R. F., Kay D. R., Wagner J. G. The in vitro loss of penicillamine in plasma, albumin solutions and whole blood: implications for pharmacokinetic studies of penicillamine. Life Sciences 1980; 27: 189–198
  • Boulding J. E., Baker R. A. The treatment of metal poisoning with penicillamine. Lancet 1957; 2: 985
  • Bourke C. E., Miners J. O., Birkett D. J. Reversible metabolism of D-penicillamine in the rat. Drug Metabolism and Disposition 1984; 12: 798–799
  • Brownlee G., Woodbine M. The antibacterial activity of some synthetic compounds related to penicillin. British Journal of Pharmacology and Chemotherapy 1948; 3: 305–308
  • Budzikiewicz H., Djerassi C., Williams D. H. Interpretation of Mass Spectra of Organic Compounds. Holden-Day, San Francisco 1964; 61
  • Chandra P., Sarin P. S. Selective inhibition of replication of the AIDS-associated virus HTLV-III/LAV by synthetic D-penicillamine. Arzneimittel-Forschung 1986; 36: 184–186
  • Committee ON Medical Research, Washington AND Medical Research Council, London. Chemistry of penicillin. Science 1945; 102: 627–629
  • Crawhall J. C., Thompson C. J. Cystinuria: Effect of D-penicillamine on plasma and urinary cystine concentrations. Science 1965; 147: 1459–1460
  • Crawhall J. C., Scowen E. F., Watts R. W. E. Effects of penicillamine on cystinuria. British Medical Journal 1963; 1: 588–590
  • Duffin W. M., Wilkinson S. British patent. 585,413, 1947, Resolution of penicillamine. Feb. 6th. (Wellcome Foundation)
  • Gibbs K., Walshe J. M. Studies with 35S-labelled DL-penicillamine in patients with Wilson's disease. Quarterly Journal of Medicine, New Series, 40, Continuous Series 1971; 63: 275–287
  • Hartley B. S., Walshe J. M. Penicillamine and mixed disulphide excretion in Wilson's disease. Lancet 1963; 2: 434–435
  • Jawetz E., Gunnison J. R., Coleman V. R. Observations on the mode of action of antibiotic synergism and antagonism. Journal of General Microbiology 1954; 10: 191–198
  • Krikunov V. P., Golovanov N. P., Shibalkin V. D., Podymov V. K., Radchenko I. V., Anderson A. A. Acetylation phenotype in patients with rheumatoid arthritis and therapy with D-penicillamine. Postudila 1978; 9: 63–64
  • Kyogoku K., Inoue K., Otake T., Noda K., Ohzeki M. Determination of D-penicillamine and its metabolites in blood and urine. Yakugaku Zasshi 1982; 102: 322–327
  • MacDonald W. B., Fellers F. X. Penicillamine in the treatment of patients with cystinuria. Journal of the American Medical Association 1966; 197: 396–402
  • Milne M. D. Renal pharmacology. Annual Review of Pharmacology 1965; 5: 119–136
  • Mitchell S. C., Waring R. H. Detection of inorganic sulphate and other anions on paper and thin-layer chromatograms. Journal of Chromatography 1978; 166: 341–343
  • Mitchell S. C., Waring R. H. The early history of xenobiotic sulphoxidation. Drug Metabolism Reviews 1985–86; 16: 255–284
  • Moffat E. D., Lytle R. I. Polychromatic technique for the identification of amino acids on paper chromatograms. Analytical Chemistry 1959; 31: 926–928
  • Morita K., Kobayashi S. Isolation and synthesis of lenthionine, an odorous substance of shiitake an edible mushroom. Tetrahedron Letters 1966; 573–577
  • Multicentre Trial Group. Controlled trial of D-(—)-penicillamine in severe rheumatoid arthritis. Lancet 1973; 1: 275–280
  • Nygaard O., Eldjarn L., Nakken K. F. Studies on the metabolism of thioacetamide-S35 in the intact rat. Cancer Research 1954; 14: 625–628
  • Osborn S. B., Walshe J. M. Effects of penicillamine and dimercaprol on turnover of copper in patients with Wilson's disease. Lancet 1958; 1: 70–73
  • Patterson M. S., Greene R. C. Measurement of low energy beta-emitters in aqueous solution by liquid scintillation counting of emulsions. Analytical Chemistry 1965; 37: 584–857
  • Patzschke K., Wegner L. A. Pharmakokinetische untersuchunge nach applikation von 14C-D-penicillamin an ratten. Arzneimittel-Forschung 1977; 27: 1152–1158
  • Patzschke K., Wegner L., Kaller H., Horster F. A. Pharmakokinetische untersuchungen nach oraler applikation von radioaktiv markiertem D-penicillamin an probanden. Zeitschrift fur Rheumatologie 1977; 36: 96–105
  • Perret D. An outline of D-penicillamine metabolism. Proceedings of the Royal Society of Medicine 1977; 70(Suppl. 3)61–64
  • Perret D. The metabolism and pharmacology of D-penicillamine in man. Jounal of Rheumatology 1981; 8(Suppl. 7)41–50
  • Perret D., Sneddon W., Stephens A. D. Studies on D-penicillamine metabolism in cystinuria and rheumatoid arthritis: Isolation of S-methyl-D-penicillamine. Biochemical Pharmacology 1976; 25: 259–264
  • Peterson J. I. A carbon dioxide collection accessory for the rapid combustion apparatus for preparation of biological samples for liquid scintillation analysis. Analytical Biochemistry 1969; 31: 204–210
  • Peterson J. I., Wagner F., Siegel S., Nixon W. A system for convenient combustion preparation of tritiated biological samples for scintillation analysis. Analytical Biochemistry 1969; 31: 189–203
  • Planas-Bohne F. Pharmakokinetische untersuchungen an 14C-markiertem penicillamin. Arzneimittel-Forschung 1972; 22: 1426–1433
  • Planas-Bohne F. On the metabolism of D-penicillamine. Zeitschrift fur Naturforschung 1973; 28c: 774
  • Planas-Bohne F. Metabolism and pharmacokinetics of penicillamine in rats—an overview. Journal of Rheumatology 1981; 8: 35–40
  • Ruiz-Torres A., Kurten I. Zur pharmakokinetik und zum sotffwechsel von D- und L-penicillamin. Arzneimittel-Forschung 1974; 24: 1258–1261
  • Tabachnick M., Eisen H. N., Levine B. A new mixed disulphide: Penicillamine-cysteine. Nature 1954; 174: 701–702
  • Toennies G., Kolb J. J. Techniques and reagents for paper chromatography. Analytical Chemistry 1951; 23: 823–826
  • Walshe J. M. Penicillamine: a new oral therapy for Wilson's disease. American Journal of Medicine 1956; 21: 487–495
  • Weisiger R. A., Jakoby W. B. Chpt. 7. Enzymatic Basis of Detoxication, W. B. Jakoby. Academic Press Inc., U.S.A. 1980; Vol. 2: 131–140
  • Williams D. H., Fleming I. Spectroscopic Methods in Organic Chemistry2nd edition. McGraw-Hill Ltd, U.K. 1973; 65
  • Wilson J. E., du Vigneaud V. L-Penicillamine as a metabolic antagonist. Science 1948; 10: 653
  • Wilson J. E., du Vigneaud V. Inhibition of the growth of the rat by L-penicillamine and its prevention by aminoethanol and related compounds. Journal of Biological Chemistry 1950; 184: 63–70

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