Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 3
4
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Disposition of 6-chloro-2-pyridylmethyl nitrate, a new anti-anginal compound, in rats and dogs

, , , , , & show all
Pages 291-300 | Received 03 Apr 1987, Accepted 01 Sep 1987, Published online: 30 Sep 2009

References

  • Chism J. P., Turner M. J., Richert D. E. The metablism and excretion of mononitrotoluenes by Fischer 344 rats. Drug Metabolism and Disposition 1984; 12: 596–602
  • de Bethizy J. D., Rickert D. E. Metabolism of nitrotoluenes by freshly isolated Fischer 344 rat hepatocytes. Drug Metabolism and Disposition 1984; 12: 45–50
  • Dutton G. J. Uridine diphosphate glucuronic acid as glucuronyl donor in the synthesis of -Ester‘, aliphatic and steroid glucuronides. Biochemical Journal 1956; 64: 693–701
  • Gombar C. T., Straub K., Levandoski P., Gutzait L., Swagzdis J., Garvie C., Joseph G., Potts B. D., Mico B. A. Pharmacokinetics, metabolism, and disposition of 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine (SK&F 86466) in rats and dogs. Drug Metabolism and Disposition 1986; 14: 540–548
  • Hoffmann K. J. Identification of the main urinary metabolites of omeprazole after an oral dose to rats and dogs. Drug Metabolism and Disposition 1986; 14: 341–348
  • Lutz R. J., Dedrick R. L., Matthews H. B., Eling T. E., Anderson M. W. A preliminary pharmacokinetics model for several chlorinated biphenyls in the rat. Drug Metabolism and Disposition 1977; 5: 386–396
  • Metzler C. M., Elfring G. K., McEwen A. J. A package of computer programs for pharmacokinetic modeling. Biometrics 1974; 30: 562–563
  • Ohtsuka M., Sakai S., Kusunoki T., Tanaka T., Terai T., Ono T. Cardiovascular activity of FR46171, a new pyridine alcohol derivative. The Japanese Journal of Pharmacology 1985; 39: 138P, (supplement)
  • Okuda H., Miwa K., Nojima H., Watanabe T. Inactivation of the carcinogen, 5-hydroxymethylchrysene, by glutathione conjugation via a sulphate ester in hepatic cytosol. Biochemical Pharmacology 1986; 35: 4573–4576
  • Renner G. Formation of pentachlorothioanosole from N-acetyl-S-(pentachlorophenyl) cysteine in blood and liver of rats in vivo. Life Sciences 1983; 33: 1427–1431
  • Satake N., Usui H., Kurahashi K., Fujiwara M., Shibata S. The new inhibitory agents of receptor operated Ca2+ channels and intracellular Ca2+ release in the vascular smooth muscles. The Japanese Journal of Pharmacology 1986; 40: 13P, (supplement)
  • Tateish M., Suzuki S., Shimizu H. The metabolism of bromazepam in the rat. Identification of mercapturic acid and its conversion in vitro to methylthiobromazepam. Biochemical Pharmacology 1978; 27: 809–810
  • Wood J. L. Biochemistry of mercapturic acid formation. Metabolic conjugation and metabolic hydrolysis, W. H. Fishman. Academic Press, New York, London 1970; 261–299

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.