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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 3
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Original Article

Fungal transformations of antihistamines: Metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives

Carl E. Cerniglia National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA
,
Eugene B. Hansen National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA
,
Kenneth J. Lambert National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA
,
Walter A. Korfmacher National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA
&
Dwight W. Miller National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA
Pages 301-312 | Received 06 Apr 1987, Accepted 02 Oct 1987, Published online: 30 Sep 2009

References

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  • Rao G. S., Krishna G., Gillette J. R. Enzymatic formation of chemically reactive metabolites of N-nitrosodesmethyl tripelennamine by a mechanism other than N-dealkylation. Biochemical Pharmacology 1975a; 24: 1707–1711
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  • Thompson H. C., Jr., Holder C. L. Trace analysis of the antihistamines methapyrilene hydrochloride, pyrilamine maleate, and triprolidine hydrochloride monohydrate in animal feed, human urine, and wastewater by high-performance liquid chromatography and gass chromatography with nitrogen-phosphorus detection. Journal of Chromatography 1984; 285: 251–264

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