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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 4
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Original Article

The enterohepatic circulation of perhexiline metabolites in the male Wistar rat

R. G. Cooper Department of Medicine, P.O. Box 147, Liverpool, L69 3BX, UK; Department of Surgery, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, UK
,
S. A. Jenkins Department of Medicine, P.O. Box 147, Liverpool, L69 3BX, UK; Department of Surgery, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, UK
,
D. A. Price Evans Director of Medicine, Riyadh Armed Forces Hospital, P.O. Box 7897, Riyadh, 11159, Kingdom of Saudi Arabia
&
A. H. Price Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
Pages 389-396 | Received 29 Apr 1987, Accepted 27 Nov 1987, Published online: 30 Sep 2009

References

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  • Amoah A. G. B., Gould B. J., Parke D. V., Lockhart J. D. F. Further studies on the pharmacokinetics of perhexiline in the human. Xenobiotica 1986; 16: 63–68
  • Boxenbaum H. G., Jodhka G. S., Ferguson A. C., Riegelman S., MacGregor T. R. The influence of bacterial gut hydrolysis on the fate of orally administered isonicotinuric acid in man. Journal of Pharmacokinetics and Biopharmaceutics 1974; 2: 211–237
  • Cooper R. G., Evans D. A. P., Whidley E. J. Polymorphic hydroxylation of perhexiline maleate in man. Journal of Medical Genetics 1984; 21: 27–33
  • Cooper R. G., Harper G., Price A. H., Evans D. A. P., Lockhart J. D. F. Simultaneous determination of perhexiline and its monohydroxy metabolites in biological fluids, by gas chromatography-electron capture detection. Journal of Chromatography, Biomedical Applications 1986; 381: 305–315
  • Cooper R. G., Evans D. A. P., Price A. H. Studies on the metabolism of perhexiline in man. European Journal of Clinical Pharmacology 1987; 32: 569–576
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  • Oates N. S., Shah R. R., Idle J. R., Smith R. L. Genetic pohymorphism of phenofrmin 4-hydroxylation. Clinical Pharmacology and Therapeutics 1982; 32: 81–89
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  • Shah R. R., Oates N. S., Idle J. R., Smith R. L., Lockhart J. D. Impaired oxidation of debrisoquine in patients with perhexiline neuropathy. British Medical Journal 1982; 284: 295–299
  • Smith R. L. Species differences in the biliary excretion of drugs. Proceedings of the European Society for the Study of Drug Toxicity 1970; 11: 19–32
  • Smith R. L. The excretory function of bile. Chapman and Hall, London 1973; 76–93
  • Tse F. L. S., Ballard F., Skinn J. Estimating the fraction re-absorbed in drugs undergoing enterohepatic circulation. Journal of Pharmacokinetics and Biopharmaceutics 1982; 10: 455–461
  • Wright G. J., Zeiger A. V., Lemieux R. E., McRoberts E., Carr A. A., Leeson G. A., Lang J. F. Perhexiline maleate; characterisation and identification of metabolic products. Merrell Research Centre, Merrell National Laboratories, Division of Richardson-Merrell Inc., Cincinnatti, Ohio 1972
  • Wright G. J., Leeson G. A., Zeiger A. V., Lang J. F. The absorption, excretion and metabolism of perhexiline maleate by the human. Postgraduate Medical Journal 1973; 49(Supplement 3–8)15

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