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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 4
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Original Article

Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage

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Pages 397-405 | Received 29 Apr 1987, Accepted 13 Nov 1987, Published online: 30 Sep 2009

References

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  • Biological Handbook. Blood and other body fluids, D. S. Ditmer. Federation of American Societies for Experimental Biology, Washington, DC 1961; 5
  • Dixit R., Teel R. W., Daniel F. B., Stoner G. D. Inhibition of benzo‘a’pyrene and benzo‘a’pyrene-trans-7,8-diol metabolism and DNA binding in mouse lung explants by ellagic acid. Cancer Research 1985; 45: 2951–2956
  • Dixit R., Gold B. Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid. Proceedings National Academy Science, USA 1986; 83: 8039–8043
  • Doyle B., Griffiths L. A. The metabolism of ellagic acid in the rat. Xenobiotica 1980; 10: 247–256
  • Lesca P. Protective effects of ellagic acid and other plant phenols on benzo‘a’pyrene-induced neoplasia in mice. Carcinogenesis 1983; 4: 1651–1653
  • Mandal S., Shivapurkar N., Superczynski M., Stoner G. D. Inhibition of methylbenzylnitrosamine-induced esophageal tumours in rats by ellagic acid. Proceedings American Association for Cancer Research 1986; 27: 124
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  • Mukhtar H., Das M., Bickers D. R. Inhibition of 3-methylcholanthrene-induced skin tumourigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water. Cancer Research 1986; 46: 2262–2265
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  • Sayer J. M., Yagi H., Wood A. W., Conney A. H., Jerina D. M. Extremely facilt reaction between the ultimate carcinogen benzo‘a’pyrene 7,8-diol-9,10-epoxide and ellagic acid. Journal of the American Chemical Society 1982; 104: 5562–5564
  • Smart R. C., Huant M. T., Chang R. L., Sayer J. M., Jerina D. M., Wood A. W., Conney A. H. Effects of ellagic acid and 3–0-decylellagic acid on the formation of benzo‘a’pyrene-derived DNA adducts in vivo and on the tumourigenicity of 3-methylcholanthrene in mice. Carcinogenesis 1986a; 7: 1669–1675
  • Smart R. C., Huang M. T., Chang R. L., Sayer J. M., Jerina D. M., Conney A. H. Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3–0-decylellagic acid and 3,3′-di-0-methylellagic acid in mice. Carcinogenesis 1986b; 7: 1663–1667
  • Van Tassel R. Bezoars. Janus 1973; 60: 241–259
  • Wood A. W., Huang M. T., Chang R. L., Newmark H. L., Lehr R. E., Yagi H., Sayer J. M., Jerina D. M., Conney A. H. Inhibition of the mutagenicity of bay-region diol epoxide polycyclic aromatic hydrocarbons by naturally occurring plant phenols: excepticnal activity of ellagic acid. Proceedings National Academy Science, USA 1982; 79: 5513–5517

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