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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 5
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Original Article

Biophysical and catalytic properties of the phenobarbital p-hydroxylase—a cytochrome P-450 dependent mixed function oxidase

Wieslawa Maniara Harrison Department of Surgical Research, School of Medicine of the University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA, 19104, USA
,
Sidney S. Levin Harrison Department of Surgical Research, School of Medicine of the University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA, 19104, USA
,
Heinz Schleyer Harrison Department of Surgical Research, School of Medicine of the University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA, 19104, USA
&
David Y. Cooper Harrison Department of Surgical Research, School of Medicine of the University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA, 19104, USA
Pages 545-550 | Received 12 Jun 1987, Accepted 18 Dec 1987, Published online: 30 Sep 2009

References

  • Cooper D. Y., Schleyer H., Thomas J. H., Vars H. M., Rosenthal O. Cytochromes P-450 and b5. Structure and Function, D. Y. Cooper, O. Rosenthal, R. Snyder, C. M. Witmer. Plenum Press, New York 1975; 81–102
  • Cooper D. Y., Touchstone J. C., Roberts J. M., Blakemore W. S., Rosenthal O. Steroid formation by adrenal tissue from hypertensives. Journal of Clinical Investigation 1958; 37: 1524–1536
  • Fenton H. J. H. LXXXIII Oxidations of tartaric acid in presence of iron. Journal of Chemical Society (London) 1894; 65: 899–910
  • Hamill S., Cooper D. Y., Schleyer H., Rosenthal O. Comparative kinetic studies of the dealkylation reaction and steroid hydroxylation in various oxygen and carbon monoxide: oxygen atmospheres. Archires of Biochemistry and Biophysics 1983a; 224: 614–624
  • Hamill S., Cooper D. Y., Schleyer H., Rosenthal O. A kinetic study comparing the light-reversal properties ot carbon monoxide inhibition of ethylmorphine, benzphetamine, 7-ethoxycoumarin dealkylation with those of hydroxylation of 17-hydroxyprogesterone and testosterone. Archives of Biochemistry and Biophysics 1983b; 224: 625–635
  • Levin S. S., Vars H. M., Schleyer H., Cooper D. Y. The metabolism and excretion of enzyme inducing doses of phenobarbital by rats with bile fistulas. Xenobiotica 1986; 16: 213–224
  • Matsubara T., Koike M., Touchi A., Tochino Y., Sugeno K. Quantitative determination of cytochrome P-450 in rat liver homogenates. Analytical Biochemistry 1976; 75: 596–603
  • Rosenthal O., Cooper D. Y. Methods of determining the photochemical action spectrum. Methods in Enzymology, R. W. Estabrook, M. E. Pullman. Academic Press, New York 1967; Vol. 10: 616–629
  • Rosenthal O., Vars H. M., Schleyer H., Cooper D. Y., Levin S. S., Touchstone J. C. Induction of cytochrome P-450 by long-term infusion of phenobarbital. Microsomes and Drug Oxidations, V. Ullrich, I. Roots, A. Hildebrandt, R. W. Estabrook, A. H. Conney. Pergamon Press, New York 1977; 568–574
  • Seago A., Gorrod J. W. The in vitro metabolism of ‘14C’-pentobarbitone and ‘14C’-phenobarbitone by hamster liver microsomes. Journal of Pharmacy and Pharmacology 1987; 38: 84–89
  • Udenfriend S., Clark C. T., Axelrod J. T., Brodie B. B. Ascorbic acid in aromatic hydroxylation: I. A model system for aromatic hydroxylation. Journal of Biological Chemistry 1954; 208: 731–739

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