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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 5
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Original Article

Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences

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Pages 561-571 | Received 14 Jul 1987, Accepted 01 Jan 1988, Published online: 30 Sep 2009

References

  • Bonelli J., Hitzenberger G., Krause W., Wendt H., Speck U. Pharmacokinetics and pharmacodynamics of mepindolol sulphate. International Journal of Clinical Pharmacology, Therapeutics and Toxicology 1980; 18: 169–176
  • Kehr W., Debus G., Neumeister R. Effects of rolipram, a novel antidepressant, on monoamine metabolism in rat brain. Journal of Neural Transmission 1985; 63: 1–12
  • Przegalinski E., Bigajska K., Lewandowska A. The influence of rolipram in the central serotoninergic system. Pharmacopsychiat 1981; 14: 162–166
  • Schmidt B., Volk R., Schultz J. E. Induction of enteral noradrenergic subsensitivity after long-term treatment of rats with rolipram. Naunyn Schmiedeberg's Arch. Pharmacol 1985; 329: R92, (Suppl.)
  • Wachtel H. Characteristic behavioral alterations in rats induced by rolipram and other selective adenosine cyclic 3′,5′-monophosphate phosphodiesterase inhibitors. Psychopharmacology 1982; 77: 309–316
  • Wachtel H. Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′-5′-monophosphate phosphodiesterase inhibitors. Neuropharmacology 1983; 22: 267–272
  • Zeller E., Stief H. J., Pflug B., Sastre-y-Hernández M. Results of a phase II study of the antidepressant effect of rolipram. Pharmacopsychiat 1984; 17: 188–190

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