Disposition of (—)-fenfluramine and its active metabolite, (—)-norfenfluramine in rat: A single dose-proportionality study

References

• Ashley J. J., Levy G. Inhibition of diphenylhydantoin elimination by its major metabolite. Research Communications in Chemical Pathology and Pharmacology 1972; 4: 297–306
   PubMedGoogle Scholar
• Belvedere G., Tognoni G., Morselli P. L. A new sensitive gas-chromatographic method for the determination of fenfluramine in biological specimens. European Journal of Clinical Pharmacology 1972; 5: 62–64
   Web of Science ®Google Scholar
• Benet L. Z., Galeazzi R. L. Noncompartmental determination of the steady-state volume of distribution. Journal of Pharmaceutical Science 1979; 68: 1071–1074
   PubMed Web of Science ®Google Scholar
• Bettini E., Ceci A., Spinelli R., Samanin R. Neuroleptic-like effects of the 1-isomer of fenfluramine on striatal dopamine release in freely moving rats. Biochemical Pharmacology 1987; 36: 2387–2391
   PubMed Web of Science ®Google Scholar
• Boxenbaum H. Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin. Journal of Pharmacokinetics and Biopharmaceutics 1980; 8: 165–176
   PubMedGoogle Scholar
• Caccia S., Ballabio M., Guiso G., Rocchetti M., Garattini S. Species differences in the kinetics and metabolism of fenfluramine isomers. Archives Internationales de Pharmacodynamie et de Therapie 1982; 258: 15–28
   PubMedGoogle Scholar
• Caccia S., Conforti I., Duchier J., Garattini S. Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d- and dl-fenfluramine for 15 days. European Journal of Clinical Pharmacology 1985; 29: 221–224
   PubMed Web of Science ®Google Scholar
• Caccia S., Dagnino G., Garattini S., Guiso G., Madonna R., Zanini M. G. Kinetics of fenfluramine isomers in the rat. European Journal of Drug Metabolism and Pharmacokinetics 1981; 6: 297–301
   PubMedGoogle Scholar
• Campbell D. B. Pharmacokinetics of Amphetamine and Fenfluramine after Therapeutic Dosage and Overdosage. Ph.D. Thesis, University of London. 1978
   Google Scholar
• Campbell D. B., Richards R. P., Caccia S., Garattini S. Stereoselective metabolism and the fate of fenfluramine in animals and man. Development of Drugs and Modern Medicines, J. W. Gorrod, G. G. Gibson, M. Mitchard. Horwood, Chichester 1986; 298–311
   Google Scholar
• Covell D. G., Abbrecht P. H., Berman M. The effect of hepatic uptake on the disappearance of warfarin from the plasma of rats: A kinetic analysis. Journal of Pharmacokinetics and Biopharmaceutics 1983; 11: 127–145
   PubMedGoogle Scholar
• Debbas N. M. G., Ings R. M. J., Gordon B. H., Richards R. P., Jackson S. H. D., Turner P. (+)-fenfluramine: Relative and absolute bioavailability of a solution compared with a capsule. British Journal of Clinical Pharmacology 1985; 20: 549P
   Web of Science ®Google Scholar
• Fracasso C., Guiso G., Garattini S., Caccia S. Disposition of d-fenfluramine in lean and obese rats. Appetite 1988; 10: 45–55
   PubMed Web of Science ®Google Scholar
• Garattini S., Bizzi A., Caccia S., Mennini T., Samanin R. Progress in assessing the role of serotonin in the control of food intake. Clinical Neuropharmacology 1987, in press
   Web of Science ®Google Scholar
• Garattini S., Caccia S., Mennini T., Samanin R., Consolo S., Ladinsky H. Biochemical pharmacology of the anorectic drug fenfluramine: A review. Current Medical Research and Opinion 1979; 6(suppl. 1)15–27
   Google Scholar
• Geller E., Ritvo E. R., Freerman B. J., Yuwiler A. Preliminary observations on the effect of fenfluramine on blood serotonin and symptoms in three autistic boys. New Zealand Journal of Medicine 1982; 307: 165–169
   Google Scholar
• Gibaldi M., Perrier D. Pharmacokinetics2nd ed. Marcel Dekker, New York 1982
   Google Scholar
• Glowinski J., Iversen L. L. Regional studies of catecholamines in the rat brain—I. The disposition of ‘3H’norepinephrine, ‘3H’dopamine and ‘3H’dopa in various regions of the brain. Journal of Neurochemistry 1966; 13: 655–669
   PubMed Web of Science ®Google Scholar
• Invernizzi R., Berettera C., Garattini S., Samanin R. D- and 1-isomers of fenfluramine differ markedly in their interaction with brain serotonin and catecholamines in the rat. European Journal of Pharmacology 1986; 120: 9–15
   PubMed Web of Science ®Google Scholar
• Lowry O. H., Rosenbrough N. J., Parr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Morgan C. D., Cattabeni F., Costa E. Methamphetamine, fenfluramine and their N-dealkylated metabolites: Effect on monoamine concentrations in rat tissues. Journal of Pharmacology and Experimental Therapeutics 1972; 180: 127–134
   PubMed Web of Science ®Google Scholar
• Nies A. S., Shand D. G., Wilkinson G. R. Altered hepatic blood flow and drug disposition. Clinical Pharmacokinetics 1976; 1: 135–155
   PubMedGoogle Scholar
• Pinder R. M., Brogden R. N., Sawyer P. R., Speight T. M., Avery G. S. Fenfluramine: A review of its pharmacological properties and therapeutic efficacy in obesity. Drugs 1975; 10: 241–323
   PubMed Web of Science ®Google Scholar
• Ritvo E. R., Freeman B. J., Geller E., Yuwiler A. Effects of fenfluramine on 14 outpatients with the syndrome of autism. Journal of the American Academy of Child Psychiatry 1983; 22: 529–558
   Google Scholar
• Toon S., Rowland M. Structure-pharmacokinetic relationships among the barbiturates in the rat. Journal of Pharmacology and Experimental Therapeutics 1983; 225: 752–763
   PubMed Web of Science ®Google Scholar
• Vermeulen N. P. E., Danhof M., Setiawan I., Thio T. H., Breimer D. D. Disposition of hexobarbital in the rat. Estimation of -first–pass elimination and influence of ether anesthesia. Journal of Pharmacology and Experimental Therapeutics 1983; 226: 201–205
   PubMed Web of Science ®Google Scholar
• Weder H. J., Bickel M. H. Interactions of drugs with proteins II: Experimental methods, treatment of experimental data, and thermodynamics of binding reactions of thymoleptic drugs and model dyes. Journal of Pharmaceutical Sciences 1970; 59: 1563–1569
   PubMed Web of Science ®Google Scholar
• Whittaker V. P., Barker L. A. The subcellular fractionation of brain tissue with special reference to the preparation of synaptosomes and their component organelles. Methods of Neurochemistry, R. Fried. Marcell Dekker, New York 1972; Vol. 2: 1–50
   Google Scholar