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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 7
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Original Article

Pre-systemic metabolism of viprostol in the monkey following oral and topical administration

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Pages 797-802 | Received 27 May 1987, Accepted 18 Dec 1987, Published online: 30 Sep 2009

References

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  • Birnbaum J. E., Chan P. S., Cervoni P., Dessy F., Van Humbeeck L. Cutaneous erythema and blood pressure lowering effects of topically applied 16-vinyl prostaglandins. Prostaglandins 1982b; 23(2)185–199
  • Chan P. S., Cervoni P., Ronsberg M. A., Accomando R. C., Quirk G. J., Scully P. A., Lipchuck L. M. Antihypertensive activity of dl-15-deoxy-16–1-hydroxy-15-(α/β)-vinyl prostaglandin E2 methyl ester (CL 115,347), a new orally and transdermally long-acting antihypertensive agent. Journal of Pharmacology and Experimental Therapeutics 1983; 226: 726–732
  • Cosulich D. B., Perkinson N. A., Batra V. K. Capillary gas chromatographic-mass spectrometric analysis of 15-deoxy-16-hydroxy-16-vinylprostaglandin E2. Journal of Pharmaceutical Sciences 1985; 74(1)76–78
  • Nicolau G., Baughman R. A., Tonelli A., McWilliams W., Shiltz J., Yacobi A. Deposition of viprostol (a synthetic PGE2 vasodilator) in the skin following topical administration to laboratory animals. Xenobiotica 1987; 17: 1113–1120
  • Nicolau G., Cosulich D. B., Tonelli A., Chen S. M., Pruzinsky M. S., Blum D. Metabolism of viprostol—a synthetic vasodilator PGE2 analog. Prostaglandins 1986; 31(No. 4)811–827
  • Yacobi A., Baughman R. A., Cosulich D. B., Nicolau G. Method for determination of first-pass metabolism in human skin. Journal of Pharmaceutical Sciences 1985; 73(10)1499–1500

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