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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 9
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Original Article

Oxidative Deamination of Alicyclic Primary Amines by Liver Microsomes from Rats and Rabbits

Hideo Kurebayashi Division of Medical Chemistry, National Institute of Hygienic Sciences, Kamiyoga, Setagaya-ku, Tokyo, 158, Japan
,
Akira Tanaka Division of Medical Chemistry, National Institute of Hygienic Sciences, Kamiyoga, Setagaya-ku, Tokyo, 158, Japan
,
Tsutomu Yamaha Division of Medical Chemistry, National Institute of Hygienic Sciences, Kamiyoga, Setagaya-ku, Tokyo, 158, Japan
&
Atsushi Tatahashi Division of Medical Chemistry, National Institute of Hygienic Sciences, Kamiyoga, Setagaya-ku, Tokyo, 158, Japan
Pages 1039-1048 | Received 26 Oct 1987, Accepted 30 May 1988, Published online: 30 Sep 2009

References

  • Axelrod J. The enzymatic deamination of amphetamine. Journal of Biological Chemistry 1955; 214: 753–763
  • Beckett A. H., Al‐Sarraj S. The mechanism of oxidation of amphetamine enantiomorphs by liver microsomal preparations from different species. Journal of Pharmacy and Pharmacology 1972; 24: 174–176
  • Brodie B. B., Gillette J. R., La Du B. M. Enzymatic metabolism of drugs and other foreign compounds. Annual Review of Biochemistry 1958; 27: 427–454
  • Dring L. G., Smith R. L., Williams R. T. The metabolic fate of amphetamine in man and other species. Biochemical Journal 1970; 116: 425–435
  • Fuller R. W., Pauli C. J., Molloy B. B. Metabolism of amphetamine and β,β‐difluoroamphetamine in phenobarbital‐treated rats. Biochemical Pharmacology 1973; 22: 2059–2061
  • Hewick D. S., Fouts J. R. The metabolism in vitro and hepatic microsomal interactions of some enantiomeric drug substances. Biochemical Journal 1970; 117: 833–841
  • Hoffstrom I., Orrenius S. The interaction of various N‐substituted amphetamines with cytochrome P‐450 of rabbit liver microsomes. FEBS Letters 1973; 31: 205–208
  • Hucker H. B., Michniewicz B. M., Rhodes R. E. Phenylacetone oxime‐an intermediate in the oxidative deamination of amphetamine. Biochemical Pharmacology 1971; 20: 2123–2128
  • Irino O., Tateishi M., Miura C., Fukawa K. Studies on absorption, biotransformation and excretion of drug. II. Metabolism of 2‐indanamine. Chemical and Pharmaceutical Bulletin 1972; 20: 734–740
  • Kurebayashi H., Tanaka A., Yamaha T. Oxidative deamination of cyclohexylamine and its homologues by rabbit liver microsomes. Biochemical Pharmacology 1979; 28: 1719–1726
  • Kurebayashi H., Tanaka A., Yamaha T. Oxygen‐18 studies on the oxidative deamination mechanism of alicyclic primary amines in rabbit liver microsomes. Archives of Biochemistry and Biophysics 1982; 215: 433–443
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–268
  • Omura T., Sato R. The carbon monoxide‐binding pigment of liver microsomes. Journal of Biological Chemistry 1964; 239: 2370–2385
  • Pauli C. J., McMahon R. E. The mechanism of microsomal deamination: heavy isotope studies. Drug Metabolism and Disposition 1973; 1: 337–340
  • Pauli C. J., Wang N., McMahon R. E. The mechanism of the oxidation of d‐amphetamine by rabbit liver oxygenase. Oxygen‐18 studies. Biochemical and Biophysical Research Communications 1971; 43: 1204–1209
  • Renwick A. G., Williams R. T. The metabolites of cyclohexylamine in man and certain animals. Biochemical Journal 1972; 129: 857–867
  • Schenkman J. B. Studies on the nature of the type I and type II spectral changes in liver microsomes. Biochemistry 1970; 9: 2081–2091
  • Schenkman J. B., Remmer H., Estabrook R. W. Spectral studies of drug interaction with hepatic microsomal cytochrome. Molecular Pharmacology 1967; 3: 113–123
  • Tatsumi K., Ishigai M. Oxime‐metabolizing activity of liver aldehyde oxidase. Archives of Biochemistry and Biophysics 1987; 253: 413–418
  • Wright J., Cho A. K., Gal J. The metabolism of amphetamine in vitro by rabbit liver preparations: a comparison of R(‐) and S(+) enantiomers. Xenobiotica 1977; 7: 257–266

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