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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 10
38
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Original Article

Effects of an Nadph-Generating System on Primaquine Degradation by Hamster Liver Fractions

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Pages 1165-1178 | Received 23 Mar 1988, Accepted 03 Jun 1988, Published online: 30 Sep 2009

References

  • Allahyari R., Strother A., Fraser I. M., Verbiscar A. J. Synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin‐producing and glutathione‐depleting activity in human erythrocytes. Journal of Medicinal Chemistry 1984; 29: 407–410
  • Baker J. K., McChesney J. D., Hufford C. D., Clark A. M. High‐performance liquid chromatographic analysis of the metabolism of primaquine and the identification of a new mammalian metabolite. Journal of Chromatography 1982; 230: 69–77
  • Baty J. D., Evans A. P., Robinson P. A. The identification of 6‐methoxy 8‐aminoquiniline as a metabolite of primaquine in man. Biomedical Mass Spectrometry 1975; 2: 304–306
  • Fraser I. M., Vesell E. S. Effects of metabolites of primaquine and acetanilid on normal and glucose‐6‐phosphate dehydrogenase‐deficient erythrocytes. Journal of Pharmacology and Experimental Therapeutics 1968; 162: 155–165
  • Johnson C., Beedham C., Stell J. G. P. Reaction of 1‐amino and 1‐chlorophthalazine with mammalian molybdenum hydroxylase in vitro. Xenobiotica 1987; 17: 17–24
  • Juchau M. R. Mechanisms of drug biotransformation reactions in the placenta. Federation Proceedings 1972; 31: 48–51
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurements with Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Nora M. V., Parkhurst G. W., Thomas R. W., Carson P. E. High‐performance liquid chromatographic‐electrochemical assay method for primaquine in plasma and urine. Journal of Chromatography 1984; 307: 451–456
  • Strother A., Fraser I. M., Tilton B. E. Studies of the metabolism of the antimalarial agent primaquine. Abstracts, Sixth International Congress of Pharmacology. Helsinki, Finland 1975; 1400
  • Strother A., Allahyari R., Buchholz J., Fraser I. M., Tilton B. E. In vitro metabolism of the antimalarial agent primaquine by mouse liver enzymes and identification of a methemoglobin‐forming metabolite. Drug Metabolism and Disposition 1984; 12: 35–44
  • Summerfied M., Tudhope G. R. Studies with primaquine in vitro: Superoxide radical formation and oxidation of haemoglobin. British Journal of Pharmacology, 6: 319–323
  • Wildenaur D. B., Oehlmann C. E. Interaction of cyclophosphamide metabolites with membrane proteins: An in vitro study with rabbit liver microsomes and human red blood cells. Effect of thiols. Biochemical Pharmacology 1982; 31: 3535–3541

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