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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 10
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Original Article

A New Metabolite of Diclofenac Sodium in Human Plasma

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Pages 1191-1197 | Received 29 Mar 1988, Accepted 07 Jun 1988, Published online: 30 Sep 2009

References

  • Bakke O. M. O‐Methylation of simple phenols in the rat. Acta pharmacologica et toxicologica 1970; 18: 28–38
  • Blum W., Richter W. J. Parallel flame ionization detection‐total ion current recording in capillary gas chromatography‐chemical ionization mass spectrometry. Journal of Chromatography 1977; 132: 249–259
  • Degen P. H., Dieterle W., Schneider W., Theobald W., Sinterhauf M. Pharmaco‐kinetics of diclofenac and five metabolites after single doses in healthy volunteers and after repeated doses in patients. Xenobiotica 1988, in presss
  • Fowler P. D. Voltarol: diclofenac sodium. Clinics in Rheumatic Diseases 1979; 5: 427–464
  • Fowler P. D., Dawes P. T., John V. A., Shotton P. A. Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once daily administration of a 100 mg slow‐release formulation. European Journal of Clinical Pharmacology 1986; 31: 469–471
  • Godbillon J., Gauron S., Metayer J. P. High‐performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolites in biological fluids. Journal of Chromatography 1985; 338: 151–159
  • Hendershot L. C., Forsaith J. Antagonism of the frequency of phenylquinone‐induced writhing in the mouse by weak analgesics and nonanalgesics. The Journal of Pharmacology and Experimental Therapeutics 1959; 125: 237–240
  • Menassé R., Hedwall P. R., Kraetz J., Pericin C., Riesterer L., Sallmann A., Ziel R., Jaques R. Pharmacological properties of diclofenac sodium and its metabolites. Scandinavian Journal of Rheumatology, Supplement 1978; 22: 5–16
  • Newbould B. B. Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. British Journal of Pharmacology and Chemotherapy 1963; 21: 127–136
  • Schneider W., Degen P. H. Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron‐capture detection. Journal of Chromatography 1981; 217: 263–271
  • Schneider W., Degen P. H. Simultaneous determination of diclofenac sodium ana its metabolites in plasma by capillary column gas chromatography with electron‐capture detection. Journal of Chromatography 1986; 383: 412–418
  • Stierlin H., Faigle J. W. Biotransformation of diclofenac sodium (Voltaren®) in animals and in man. II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile. Xenobiotica 1979; 9: 611–621
  • Stierlin H., Faigle J. W., Sallmann A., Küng W., Richter W. J., Kriemler H. ‐P., Alt K. O., Winkler T. Biotransformation of diclofenac sodium (Voltaren®) in animals and in man. I. Isolation and identification of principal metabolites. Xenobiotica 1979; 9: 601–610
  • White H. L., Glassman A. T. A simple radiochemical assay for prostaglandin synthetase. Prostaglandins 1974; 7: 123–129
  • Winter C. A., Risley E. A., Nuss G. W. Carrageenin‐induced oedema in hind paw of the rat as an assay for anti‐inflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine 1962; 111: 544–547

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