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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 12
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Original Article

The Metabolism and Disposition of 14C-Indolidan, a Potent and Orally Active Cardiotonic Agent, in Four Species of Laboratory Animals

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Pages 1335-1345 | Received 14 May 1987, Accepted 12 Jul 1988, Published online: 30 Sep 2009

References

  • Bernstein J. R., Miller B. J., Franklin R. B. The disposition of 14C‐LY195115 (1,3‐dihydro‐3,3‐dimethyl‐5‐‘1,4,5,6‐tetrahydro‐6‐oxo‐3‐pyridazinyl‐6‐14C‐’‐2H‐indol‐2‐one), a potent cardiotonic drug, in several animal species. Federation Proceedings 1986; 45: 935, abstract # 4540
  • Hayes J. S., Pollock G. J., Wilson H., Bowling N., Robertson D. W. Pharmacology of LY195115: A potent, orally‐active cardiotonic with a long duration of action. Journal of Cardiovascular Pharmacology 1987; 9: 425–434
  • Robertson D. W., Krushinski J. H., Beedle E. E., Wyss V., Pollock D. G., Wilson H., Kauffman R. F., Hayes J. S. Dihydropyridazinone cardiotonics: discovery and inotropic activity of 1,3‐dihydro‐3,3‐dimethyl‐5‐‘1,4,5,6‐tetrahydro‐6‐oxo‐3‐pyridazinyl’ ‐2H‐indol‐2‐one. Journal of Medicinal Chemistry 1986; 29: 1832–1840
  • Vodicnik M. J., Franklin R. B., Elcombe C. R., Lech J. J. Sex steroids and drug metabolism: a sex‐related difference in hepatic microsomal ethoxyresorufin‐O‐deethylation in Sprague‐Dawley rats. Biochemical Pharmacology 1981; 30: 1091–1097

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