References
- Beckett A. H., Gorrod J. W., Jenner. The analysis of nicotine‐N‐oxide in urine in the presence of nicotine and cotinine and its application to the study of in vitro nicotine metabolism in man. Journal of Pharmacy and Pharmacology 1971; 23: 62–67
- Cundy K. C. N‐Methylation of nicotine enantiomers in the guinea pig. Ph.D. Dissertation, College of Pharmacy, University of Kentucky. 1984
- Cundy K. C., Crooks P. A. In vitro characteristics of guinea pig lung aromatic azaheterocycle N‐methyltransferase. Drug Metabolism and Disposition 1985; 13: 658–663
- Cundy K. C., Crooks P. A. Biotransformation of primary nicotine metabolites II. Metabolism of 3H‐S‐(‐)‐cotinine in the guinea pig: determination of in vivo urinary metabolites by high‐performance liquid‐radiochromatography. Xenobiotica 1987; 17: 785–792
- Cundy K. C., Crooks P. A., Godin C. S. Remarkable substrate‐inhibitor properties of nicotine enantiomers towards a guinea pig lung aromatic azaheterocycle N‐methyltransferase. Biochemical and Biophysical Research Communications 1985a; 128: 312–316
- Cundy K. C., Godin C. S., Crooks P. A. Stereospecific in vitro N‐methylation of nicotine in guinea pig tissues by an S‐adenosylmethionine‐dependent N‐methyltransferase. Biochemical Pharmacology 1985b; 34: 281–284
- Cundy K. C., Sato M., Crooks P. A. Stereospecific in vivo N‐methylation of nicotine in the guinea pig. Drug Metabolism and Disposition 1985c; 13: 175–185
- Gorrod J. W., Jenner P. The metabolism of tobacco alkaloids. Essays in Toxicology, W. J. Hayes. Academic Press, New York 1975; Vol. 6: 35–78
- Jenner P., Gorrod J. W., Beckett A. H. Factors affecting the in vitro oxidation of R‐(+)‐ and S‐(‐)‐nicotine by guinea pig liver preparations. Xenobiotica 1973a; 3: 563–572
- Jenner P., Gorrod J. W., Beckett A. H. Species variation in the metabolism of R‐(+)‐ and S‐(‐)‐nicotine by α‐C‐ and Noxidation in vitro. Xenobiotica 1973b; 3: 573–580
- Klus H., Kuhn H. A study of the optical activity of smoke nicotines. Fachliche Mitt. Oesterr. Tabakregie 1977; 17: 331–336
- Neurath G. B., Pean F. G. Gas chromatographic determination of trans‐3′‐hydroxycotinine, a major metabolite of nicotine in smokers. Journal of Chromatography Biomedical Applications 1987; 415: 400–406
- Nwosu C. G., Godin C. S., Houdi A. A., Damani L. A., Crooks P. A. Enantioselective metabolism during continuous administration of S‐(‐)‐ and R‐(+)‐nicotine isomers in the guinea pig. Journal of Pharmac and Pharacy and Pharmacology 1988, in press