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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 12
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Original Article

Pharmacokinetics of Diclofenac and Five Metabolites After Single Doses in Healthy Volunteers and After Repeated Doses in Patients

Peter H. Degen Research and Development Department, Pharmaceuticals Division, CIBA-GEIGY Ltd., Basle, Switzerland
,
Walter Dieterle Research and Development Department, Pharmaceuticals Division, CIBA-GEIGY Ltd., Basle, Switzerland
,
Werner Schneider Research and Development Department, Pharmaceuticals Division, CIBA-GEIGY Ltd., Basle, Switzerland
,
Walter Theobald Medical Department, Pharmaceuticals Division, CIBA-GEIGY Limited, Basle, Switzerland
&
Ursula Sinterhauf Clinical Research Department, CIBA-GEIGY GmbH, Frankfurt, Germany
Pages 1449-1455 | Received 29 Mar 1988, Accepted 11 Jul 1988, Published online: 30 Sep 2009

References

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  • Fowler P. D., Dawes P. T., John V. A., Shotton P. A. Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once‐daily administration of a 100mg slow‐release formulation. European Journal of Clinical Pharmacology 1986; 31: 469–471
  • Khanna S. US‐Patent No. 4510128, 1985
  • Khanna S. GB‐Patent No. 2134529, 1986
  • Riess W., Stierlin H., Faigle J. W., Geiger U. P., Gérardin A., Schmid K., Sulc M., Wagner J., Theobald W. Kinetik und Biotransformation von Diclofenac in Tier und Mensch. Therapiewoche 1976; 26: 18–24
  • Riess W., Stierlin H., Degen P. H., Faigle J. W., Gérardin A., Moppert J., Sallmann A., Schmid K., Schweizer A., Sulc M., Theobald W., Wagner J. Pharmacokinetics and metabolism of the anti‐inflammatory agent Voltaren. Scandinavian Journal of Rheumatology 1978, Supplement, 22: 17–29
  • Schneider W., Degen P. H. Simultaneous determination of diclofenac and its hydroxy metabolites by capillary column gas chromatography with electron‐capture detection. Journal of Chromatography 1981; 217: 263–271
  • Schneider W., Degen P. H. Simultaneous determination of diclofenac and its metabolites in plasma by capillary column gas chromatography with electron‐capture detection. Journal of Chromatography 1986; 383: 412–418
  • Stierlin H., Faigle J. W., Sallmann A., Kung W., Richter W. J. Biotransformation of diclofenac‐Na (Voltaren) in animals and man. Part I: Isolation and identification of the principal metabolites. Xenobiotica 1979; 9: 601–610
  • Stierlin H., Faigle J. W. Biotransformation of diclofenac‐Na (Voltaren) in animals and man. Part II: Quantitative determination of the unchanged drug and the principal phenolic metabolites in urine and bile. Xenobiotica 1979; 9: 611–621
  • Stierlin H., Faigle J. W., Colombi A. Pharmacokinetics of diclofenac sodium (Voltaren) and metabolites in patients with impaired renal function. Scandinavian Journal of Rheumatology 1978, Supplement, 22: 30–35
  • Willis J. V., Kendall M. J., Flinn R. M., Thornhill D. P., Welling P. G. The pharmacokinetics of diclofenac‐Na following intravenous and oral administration. European Journal of Clinical Pharmacology 1979; 16: 405–410

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