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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 12
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Original Article

Randomly Distributed DNA Single Strand Breaks are not Lethal for Mammalian Cells

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Pages 1481-1487 | Received 03 May 1988, Accepted 10 Aug 1988, Published online: 30 Sep 2009

References

  • Bradley M. O., Erickson L. C. Comparison of the effects of hydrogen peroxide and X‐ray irradiation on toxicity, mutation and DNA damage/repair in mammalian cells (V‐79). Biochimica et Biophysica Acta 1981; 654: 135–141
  • Cantoni O., Murray D., Meyn R. E. Effect of 3‐aminobenzamide on DNA strand‐break rejoining and cytotoxicity in CHO cells treated with hydrogen peroxide. Biochimica et Biophysica Acta 1986; 867: 135–143
  • Kohn K. W., Ewig R. A., Erickson L. C., Zwelling L. A. Measurements of strand breaks and cross‐links by alkaline elution. DNA Repair, a Laboratory Manual of Research Procedures, E. C. Friedberg, P. C. Hanawalt. Marcel Dekker Inc., New York 1981; 379–401
  • Mello‐Filho A. C., Meneghini R. In vivo formation of single‐strand breaks in DNA by hydrogen peroxide is mediated by the Haber‐Weiss reaction. Biochimica et Biophysica Acta 1984; 781: 56–63
  • Painter R. B. The role of DNA damage and repair in cell killing induced by ionizing radiation. Radiation Biology in Cancer Research, R. E. Meyn, H. R. Withers. Raven Press, New‐York 1980; 59–72
  • Roots R., Okada S. Estimation of life times and diffusion distances of radicals involved in X‐ray induced DNA strand breaks or killing of mammalian cells. Radiation Research 1975; 64: 306–312
  • Ward J. F., Blakely W. F., Joner E. I. Mammalian cells are not killed by DNA single‐strand breaks caused by hydroxyl radicals from hydrogen peroxide. Radiation Research 1985; 103: 383–392

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